K7373030 Molecular BiologyIII

Hiroshima University Syllabus

Japanese

Academic Year 2026Year School/Graduate School School of Engineering

Lecture Code K7373030 Subject Classification Specialized Education

Subject Name 分子生物学III

Subject Name
（Katakana）ブンシセイブツガクIII

Subject Name in
English Molecular BiologyIII

Instructor KUME KAZUNORI

Instructor
(Katakana) クメ　カズノリ

Campus Higashi-Hiroshima Semester/Term 3rd-Year, Second Semester, 4Term

Days, Periods, and Classrooms (4T) Mon1-2,Weds3-4：ENG 109

Lesson Style Lecture Lesson Style
(More Details) Face-to-face, Online (on-demand)

Lecture: Face-to-face, partly online (on-demand)
Examinations: Face-to-face

Credits 2.0 Class Hours/Week 4 Language of Instruction J : Japanese

Course Level 4 : Undergraduate Advanced

Course Area（Area） 26 : Biological and Life Sciences

Course Area（Discipline） 02 : Biotechnology

Eligible Students Undergraduate (Third and more year) students in Cluster 3 of the Faculty of Engineering.

Keywords Cell, Nucleic acid, Genome, Protein, Organelle, Cellular membrane, Enzyme, Metabolism, Molecular mechanism

Special Subject for Teacher Education 　 Special Subject 　

Class Status
within Educational
Program
(Applicable only to targeted subjects for undergraduate students) This class belongs to the series of Molecular Biology lectures.
Criterion referenced
Evaluation
(Applicable only to targeted subjects for undergraduate students) Program of Biotechnology
（Knowledge and Understanding）
・Acquisition of basic and advanced knowledge relating to biotechnology and life science. (Target/Lecture class)

Class Objectives
/Class Outline Objective: Molecular biology is the study of molecular basis of biological activity and is the basis of life science (including basic and applied research). The aim of this course is to develop the ability to understand biological phenomena from a quantitative perspective. Building on the knowledge of molecular mechanisms and gene regulation acquired in Molecular Biology I and II, this course reexamines these concepts from quantitative viewpoints such as size, concentration, and rate. Using examples including cell size scaling and the regulation of intracellular molecular concentrations, the course explores the physical and quantitative principles that underlie biological phenomena. In addition, basic concepts of genetics and chemical genetics will be introduced as experimental approaches for elucidating the molecular mechanisms of biological processes.

Class Schedule Part1: Size
Lesson 1: Biological phenomena from the perspective of size
Lesson 2: Cell size scaling I: the cell cycle
Lesson 3: Cell size scaling II: experimental manipulation
Lesson 4: Failure of size control: disease and aging
Part2: Concentration
Lesson 5: Intracellular molecular numbers and concentration
Lesson 6: Concentration thresholds and phase separation
Part3: Rate
Lesson 7: Reaction rates, timescale, and accuracy of information and biological errors
Lesson 8: Review of Lessons 1–7 (comprehension test)
Part4: Intracellular structures
Lesson 9: Scaling of intracellular structures I: hierarchical organization
Lesson 10: Scaling of intracellular structures II: membrane supply
Lesson 11: Scaling of intracellular structures III: intracellular transport
Lesson 12: Scaling of intracellular structures IV: cytoskeleton
Lesson 13: Scaling of intracellular structures V: Genome
Lesson 14: Scaling and function
Lesson 15: Breakdown of scaling and disease

Lesson 16: Term-end examination (face-to-face)

Text/Reference
Books,etc. Biochemistry, 4th Edition (by Donald Voet, Judith G. Voet)
Cell Biology by the Numbers, 1st Edition
Essential Cell Biology, 4th Edition

PC or AV used in
Class,etc. Handouts, Visual Materials, Microsoft Stream, moodle

(More Details)

Learning techniques to be incorporated Quizzes/ Quiz format

Suggestions on
Preparation and
Review Lessons 1-4: Review the basic concepts of cell size and the cell cycle before class. After the lecture, organize how cell size is regulated and how it relates to cell cycle progression and cellular function.
Lesson 5-6: Review the concepts of intracellular molecular numbers and concentration. After the lecture, consider the relationships between molecular number, concentration, and cell volume, and how concentration thresholds and phase separation contribute to the formation of intracellylar structures.
Lesson 7: Review the basic concepts of reaction rates and biological timescales. After the lecture, organize how reaction rates, information transfer, and error rates influence the accuracy and reliability of biological processes.
Lessons 9 - 13: Review the basic structures and functions of intracellular components such as the nucleus, membrane systems, and the cytoskeleton. After the lecture, consider how the sizes of intracellular structures scale with cell size and how these structures are regulated by molecular mechanisms.
Lesson 14-15: Review the relationships between cellular functions. After the lecture, consider how failures in scaling relationships may contribute to diseases and aging.

Requirements

Grading Method Class grade is evaluated by quizzes (30%), a comprehension test (35%), and the term-end examination (35%).

Practical Experience

Summary of Practical Experience and Class Contents based on it

Message

Other

Please fill in the class improvement questionnaire which is carried out on all classes.
Instructors will reflect on your feedback and utilize the information for improving their teaching.

Academic Year	2026Year	School/Graduate School	School of Engineering
Lecture Code	K7373030	Subject Classification	Specialized Education
Subject Name	分子生物学III
Subject Name （Katakana）	ブンシセイブツガクIII
Subject Name in English	Molecular BiologyIII
Instructor	KUME KAZUNORI
Instructor (Katakana)	クメ　カズノリ
Campus	Higashi-Hiroshima	Semester/Term	3rd-Year, Second Semester, 4Term
Days, Periods, and Classrooms	(4T) Mon1-2,Weds3-4：ENG 109
Lesson Style	Lecture	Lesson Style (More Details)	Face-to-face, Online (on-demand)
Lecture: Face-to-face, partly online (on-demand) Examinations: Face-to-face
Credits	2.0	Class Hours/Week	4	Language of Instruction	J : Japanese
Course Level	4 : Undergraduate Advanced
Course Area（Area）	26 : Biological and Life Sciences
Course Area（Discipline）	02 : Biotechnology
Eligible Students	Undergraduate (Third and more year) students in Cluster 3 of the Faculty of Engineering.
Keywords	Cell, Nucleic acid, Genome, Protein, Organelle, Cellular membrane, Enzyme, Metabolism, Molecular mechanism
Special Subject for Teacher Education		Special Subject
Class Status within Educational Program (Applicable only to targeted subjects for undergraduate students)	This class belongs to the series of Molecular Biology lectures.
Criterion referenced Evaluation (Applicable only to targeted subjects for undergraduate students)	Program of Biotechnology （Knowledge and Understanding）・Acquisition of basic and advanced knowledge relating to biotechnology and life science. (Target/Lecture class)
Class Objectives /Class Outline	Objective: Molecular biology is the study of molecular basis of biological activity and is the basis of life science (including basic and applied research). The aim of this course is to develop the ability to understand biological phenomena from a quantitative perspective. Building on the knowledge of molecular mechanisms and gene regulation acquired in Molecular Biology I and II, this course reexamines these concepts from quantitative viewpoints such as size, concentration, and rate. Using examples including cell size scaling and the regulation of intracellular molecular concentrations, the course explores the physical and quantitative principles that underlie biological phenomena. In addition, basic concepts of genetics and chemical genetics will be introduced as experimental approaches for elucidating the molecular mechanisms of biological processes.
Class Schedule	Part1: Size Lesson 1: Biological phenomena from the perspective of size Lesson 2: Cell size scaling I: the cell cycle Lesson 3: Cell size scaling II: experimental manipulation Lesson 4: Failure of size control: disease and aging Part2: Concentration Lesson 5: Intracellular molecular numbers and concentration Lesson 6: Concentration thresholds and phase separation Part3: Rate Lesson 7: Reaction rates, timescale, and accuracy of information and biological errors Lesson 8: Review of Lessons 1–7 (comprehension test) Part4: Intracellular structures Lesson 9: Scaling of intracellular structures I: hierarchical organization Lesson 10: Scaling of intracellular structures II: membrane supply Lesson 11: Scaling of intracellular structures III: intracellular transport Lesson 12: Scaling of intracellular structures IV: cytoskeleton Lesson 13: Scaling of intracellular structures V: Genome Lesson 14: Scaling and function Lesson 15: Breakdown of scaling and disease Lesson 16: Term-end examination (face-to-face)
Text/Reference Books,etc.	Biochemistry, 4th Edition (by Donald Voet, Judith G. Voet) Cell Biology by the Numbers, 1st Edition Essential Cell Biology, 4th Edition
PC or AV used in Class,etc.	Handouts, Visual Materials, Microsoft Stream, moodle
(More Details)
Learning techniques to be incorporated	Quizzes/ Quiz format
Suggestions on Preparation and Review	Lessons 1-4: Review the basic concepts of cell size and the cell cycle before class. After the lecture, organize how cell size is regulated and how it relates to cell cycle progression and cellular function. Lesson 5-6: Review the concepts of intracellular molecular numbers and concentration. After the lecture, consider the relationships between molecular number, concentration, and cell volume, and how concentration thresholds and phase separation contribute to the formation of intracellylar structures. Lesson 7: Review the basic concepts of reaction rates and biological timescales. After the lecture, organize how reaction rates, information transfer, and error rates influence the accuracy and reliability of biological processes. Lessons 9 - 13: Review the basic structures and functions of intracellular components such as the nucleus, membrane systems, and the cytoskeleton. After the lecture, consider how the sizes of intracellular structures scale with cell size and how these structures are regulated by molecular mechanisms. Lesson 14-15: Review the relationships between cellular functions. After the lecture, consider how failures in scaling relationships may contribute to diseases and aging.
Requirements
Grading Method	Class grade is evaluated by quizzes (30%), a comprehension test (35%), and the term-end examination (35%).
Practical Experience
Summary of Practical Experience and Class Contents based on it
Message
Other
Please fill in the class improvement questionnaire which is carried out on all classes. Instructors will reflect on your feedback and utilize the information for improving their teaching.

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