I7021001 Nuclear Pharmacy

Hiroshima University Syllabus

Japanese

Academic Year 2025Year School/Graduate School School of Pharmaceutical Sciences Program of Pharmaceutical Sciences

Lecture Code I7021001 Subject Classification Specialized Education

Subject Name 放射化学・放射線保健学

Subject Name
（Katakana）ホウシャセンカガク・ホウシャセンホケンガク

Subject Name in
English Nuclear Pharmacy

Instructor KURODA TERUO,SASATANI MEGUMI

Instructor
(Katakana) クロダ　テルオ,ササタニ　メグミ

Campus Kasumi Semester/Term 2nd-Year,  First Semester,  1Term

Days, Periods, and Classrooms (1T) Fri5-8：霞R404講義室

Lesson Style Lecture Lesson Style
(More Details) Face-to-face, Online (simultaneous interactive), Online (on-demand)

Lecture

Credits 2.0 Class Hours/Week 4 Language of Instruction B : Japanese／English

Course Level 4 : Undergraduate Advanced

Course Area（Area） 27 : Health Sciences

Course Area（Discipline） 03 : Pharmaceutical Sciences

Eligible Students second-year undergraduates of Pharmaceutical sciences

Keywords SDG_03 SDG_12 radioisotope，physical property，measuring methods，administration and laws，Application to medical care，radiopharmaceutical,Practical work experience, cancer, human health

Special Subject for Teacher Education 　 Special Subject 　

Class Status
within Educational
Program
(Applicable only to targeted subjects for undergraduate students)
Criterion referenced
Evaluation
(Applicable only to targeted subjects for undergraduate students) Pharmaceutical Sciences
（Knowledge and Understanding）
・The basic knowledge and understanding of basic structures, physical characters and reaction of medicine and other inorganic and organic compounds. ●quality ④
（Abilities and Skills）
・To be able to handle major analysis methods written in the Japanese Pharmacopoeia. ●quality ④
（Comprehensive Abilities）
・The research ability: the ability to select issues to be solved in the professional field of pharmacist and carry out measures and research to solve the issues.  ●quality ④ ⑤ ⑦

Medicinal Sciences
（Knowledge and Understanding）
・The knowledge of chemical compounds including medicine.

Class Objectives
/Class Outline GIO：To explain structure and the emission disintegration of the atom. To  list up kinds of the ionizing radiation and to explain the interaction with those materials. To explain the physical property of a representative radionuclide.  To explain nuclear reaction and radioactive equilibrium. To explain the principle of measurement of the radiation. To explain a property and a use of representative radiopharmaceutical.
Summary of the class：To learn radioisotope, physical property，measuring methods，administration and laws，Application to medical care，and radiopharmaceutical.

Class Schedule Lesson 1
Physics of radioisotopes (nucleus, elementary particles, interaction, nuclear force, stability, binding energy, mass defect, isotope decay law, half-life, mass energy conservation law, alpha decay, beta decay, gamma decay, origin of radioisotopes)
Interaction of radiation with matter (1) (radiation, decay diagram, scattering, ionization, excitation, bremsstrahlung)
(Kuroda)
Lesson 2
Interaction of radiation and matter (2) (annihilation gamma rays, photoelectric effect, Compton scattering, electron pair creation, shielding effect)
Measurement of Radiation (1) (gas ionization detectors, ionization chambers, proportional counters)
(Kuroda)
Lesson 3　
Radiation measurement (2) (GM counters, semiconductor counters, scintillation counters, autoradiography, pocket chambers, other measurement methods, units of radioactivity and radiation dose)
(Kuroda)
Lesson 4
Radiation Biology (target molecules, DNA damage and repair, cellular and tissue damage, acute radiation sickness, organ determinations, effective half-life, thresholds, late effects, stochastic effects, non-stochastic effects, carcinogenesis, genetic effects, population effects, dose and effects of natural radiation)　
(Sasatani)
Lesson 5
Mid-term examination
Radiation chemistry/radiochemistry (formation of radioactive materials, synthesis of radioactive compounds, characteristics of tracer material behavior, radiochemical analysis, special chemical reactions)
(Kuroda)
Lesson 6
Safe handling of radiation (safe handling of unsealed radioactive materials, in vitro exposure, in vivo exposure, shielding, safety control, exposure protection, exposure control, health examination, radioactive waste, legal system)
(Kuroda)
Lesson 7
Application of radioisotopes and radiation (application in pharmaceutical research, tracer experiments, radiopharmaceuticals and their application to basic medicine and clinical medicine (diagnosis and treatment))　
(Kuroda)
Lesson 8
Genome damage due to radiation exposure and its repair mechanisms (genome damage due to radiation and non-ionizing radiation, damage repair mechanisms, genetic diseases)
Mechanisms of carcinogenesis induced by radiation exposure (atomic bomb survivors, epidemiological studies, carcinogenesis risk, radiation carcinogenesis mechanisms (initiation, promotion))
(Sasatani)
9th
Final examination
(Kuroda)

Text/Reference
Books,etc. Text：Radiochemistry and Radiopharmaceuticals（Hideo Saji, et al）Nankodou
Reference book：Resumes

PC or AV used in
Class,etc. Text, Handouts, Microsoft Stream, Microsoft Forms, moodle

(More Details) OHP and power point

Learning techniques to be incorporated Discussions, Quizzes/ Quiz format

Suggestions on
Preparation and
Review lesson 1 and 2: Please read Chapter 1 of the textbook and review the class.  You will take a small test in a next beginning.
lesson 3: Please read Chapter 2 of the textbook and review the class.  You will take a small test in a next beginning.
lesson 4, 5, and 6: Please read Chapter 3 of the textbook and review the class.  You will take a small test in a next beginning.
lesson 7: Please read Chapter 5 of the textbook and review the class.  You will take a small test in a next beginning.
lesson 8 and 9: Please read Chapter 9 of the textbook and review the class.  You will take a small test in a next beginning.
lesson 10 and 11: Please read Chapter 10 of the textbook and review the class.  You will take a small test in a next beginning.
lesson 12 and 13: Please read Chapter 6 of the textbook and review the class.  You will take a small test in a next beginning.
lesson 14 and 15: Please read the resume  and review the class.  You will take a small test.

Requirements

Grading Method The mid-term examination 45 points, the term examination 45 points, reports 10 points; 100 points in total.

Practical Experience

Summary of Practical Experience and Class Contents based on it

Message

Other Item numbers of academic objectives: C-1-2-1), C-1-2-2), C-1-2-3), C-2-4-1), C-2-8-2), C-2-8-3), C-6-1-1), C-6-2-1), C-6-7-1), C-7-1-1), C-7-1-2), C-7-4-1), C-7-5-1)
This course is closely related to General Chemistry, Physical Chemistry of Medicines, Biophysical Chemistry, Pharmacology IV, Clinical Pharmacotherapeutics A, and Clinical Evaluation, and their relationship will be presented in the course to deepen conceptual understanding in the field of pharmacology through integrated study with these courses.

Please fill in the class improvement questionnaire which is carried out on all classes.
Instructors will reflect on your feedback and utilize the information for improving their teaching.

Academic Year	2025Year	School/Graduate School	School of Pharmaceutical Sciences Program of Pharmaceutical Sciences
Lecture Code	I7021001	Subject Classification	Specialized Education
Subject Name	放射化学・放射線保健学
Subject Name （Katakana）	ホウシャセンカガク・ホウシャセンホケンガク
Subject Name in English	Nuclear Pharmacy
Instructor	KURODA TERUO,SASATANI MEGUMI
Instructor (Katakana)	クロダ　テルオ,ササタニ　メグミ
Campus	Kasumi	Semester/Term	2nd-Year, First Semester, 1Term
Days, Periods, and Classrooms	(1T) Fri5-8：霞R404講義室
Lesson Style	Lecture	Lesson Style (More Details)	Face-to-face, Online (simultaneous interactive), Online (on-demand)
Lecture
Credits	2.0	Class Hours/Week	4	Language of Instruction	B : Japanese／English
Course Level	4 : Undergraduate Advanced
Course Area（Area）	27 : Health Sciences
Course Area（Discipline）	03 : Pharmaceutical Sciences
Eligible Students	second-year undergraduates of Pharmaceutical sciences
Keywords	SDG_03 SDG_12 radioisotope，physical property，measuring methods，administration and laws，Application to medical care，radiopharmaceutical,Practical work experience, cancer, human health
Special Subject for Teacher Education		Special Subject
Class Status within Educational Program (Applicable only to targeted subjects for undergraduate students)
Criterion referenced Evaluation (Applicable only to targeted subjects for undergraduate students)	Pharmaceutical Sciences （Knowledge and Understanding）・The basic knowledge and understanding of basic structures, physical characters and reaction of medicine and other inorganic and organic compounds. ●quality ④ （Abilities and Skills）・To be able to handle major analysis methods written in the Japanese Pharmacopoeia. ●quality ④ （Comprehensive Abilities）・The research ability: the ability to select issues to be solved in the professional field of pharmacist and carry out measures and research to solve the issues. ●quality ④ ⑤ ⑦ Medicinal Sciences （Knowledge and Understanding）・The knowledge of chemical compounds including medicine.
Class Objectives /Class Outline	GIO：To explain structure and the emission disintegration of the atom. To list up kinds of the ionizing radiation and to explain the interaction with those materials. To explain the physical property of a representative radionuclide. To explain nuclear reaction and radioactive equilibrium. To explain the principle of measurement of the radiation. To explain a property and a use of representative radiopharmaceutical. Summary of the class：To learn radioisotope, physical property，measuring methods，administration and laws，Application to medical care，and radiopharmaceutical.
Class Schedule	Lesson 1 Physics of radioisotopes (nucleus, elementary particles, interaction, nuclear force, stability, binding energy, mass defect, isotope decay law, half-life, mass energy conservation law, alpha decay, beta decay, gamma decay, origin of radioisotopes) Interaction of radiation with matter (1) (radiation, decay diagram, scattering, ionization, excitation, bremsstrahlung) (Kuroda) Lesson 2 Interaction of radiation and matter (2) (annihilation gamma rays, photoelectric effect, Compton scattering, electron pair creation, shielding effect) Measurement of Radiation (1) (gas ionization detectors, ionization chambers, proportional counters) (Kuroda) Lesson 3　 Radiation measurement (2) (GM counters, semiconductor counters, scintillation counters, autoradiography, pocket chambers, other measurement methods, units of radioactivity and radiation dose) (Kuroda) Lesson 4 Radiation Biology (target molecules, DNA damage and repair, cellular and tissue damage, acute radiation sickness, organ determinations, effective half-life, thresholds, late effects, stochastic effects, non-stochastic effects, carcinogenesis, genetic effects, population effects, dose and effects of natural radiation)　 (Sasatani) Lesson 5 Mid-term examination Radiation chemistry/radiochemistry (formation of radioactive materials, synthesis of radioactive compounds, characteristics of tracer material behavior, radiochemical analysis, special chemical reactions) (Kuroda) Lesson 6 Safe handling of radiation (safe handling of unsealed radioactive materials, in vitro exposure, in vivo exposure, shielding, safety control, exposure protection, exposure control, health examination, radioactive waste, legal system) (Kuroda) Lesson 7 Application of radioisotopes and radiation (application in pharmaceutical research, tracer experiments, radiopharmaceuticals and their application to basic medicine and clinical medicine (diagnosis and treatment))　 (Kuroda) Lesson 8 Genome damage due to radiation exposure and its repair mechanisms (genome damage due to radiation and non-ionizing radiation, damage repair mechanisms, genetic diseases) Mechanisms of carcinogenesis induced by radiation exposure (atomic bomb survivors, epidemiological studies, carcinogenesis risk, radiation carcinogenesis mechanisms (initiation, promotion)) (Sasatani) 9th Final examination (Kuroda)
Text/Reference Books,etc.	Text：Radiochemistry and Radiopharmaceuticals（Hideo Saji, et al）Nankodou Reference book：Resumes
PC or AV used in Class,etc.	Text, Handouts, Microsoft Stream, Microsoft Forms, moodle
(More Details)	OHP and power point
Learning techniques to be incorporated	Discussions, Quizzes/ Quiz format
Suggestions on Preparation and Review	lesson 1 and 2: Please read Chapter 1 of the textbook and review the class. You will take a small test in a next beginning. lesson 3: Please read Chapter 2 of the textbook and review the class. You will take a small test in a next beginning. lesson 4, 5, and 6: Please read Chapter 3 of the textbook and review the class. You will take a small test in a next beginning. lesson 7: Please read Chapter 5 of the textbook and review the class. You will take a small test in a next beginning. lesson 8 and 9: Please read Chapter 9 of the textbook and review the class. You will take a small test in a next beginning. lesson 10 and 11: Please read Chapter 10 of the textbook and review the class. You will take a small test in a next beginning. lesson 12 and 13: Please read Chapter 6 of the textbook and review the class. You will take a small test in a next beginning. lesson 14 and 15: Please read the resume and review the class. You will take a small test.
Requirements
Grading Method	The mid-term examination 45 points, the term examination 45 points, reports 10 points; 100 points in total.
Practical Experience
Summary of Practical Experience and Class Contents based on it
Message
Other	Item numbers of academic objectives: C-1-2-1), C-1-2-2), C-1-2-3), C-2-4-1), C-2-8-2), C-2-8-3), C-6-1-1), C-6-2-1), C-6-7-1), C-7-1-1), C-7-1-2), C-7-4-1), C-7-5-1) This course is closely related to General Chemistry, Physical Chemistry of Medicines, Biophysical Chemistry, Pharmacology IV, Clinical Pharmacotherapeutics A, and Clinical Evaluation, and their relationship will be presented in the course to deepen conceptual understanding in the field of pharmacology through integrated study with these courses.
Please fill in the class improvement questionnaire which is carried out on all classes. Instructors will reflect on your feedback and utilize the information for improving their teaching.

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