HJ265000 Biopolymer Chemistry

Hiroshima University Syllabus

Japanese

Academic Year 2025Year School/Graduate School School of Science

Lecture Code HJ265000 Subject Classification Specialized Education

Subject Name 生体高分子化学

Subject Name
（Katakana）セイタイコウブンシカガク

Subject Name in
English Biopolymer Chemistry

Instructor KATAYANAGI KATSUO,YASUDA KYOTA

Instructor
(Katakana) カタヤナギ　カツオ,ヤスダ　キョウタ

Campus Higashi-Hiroshima Semester/Term 3rd-Year, Second Semester, 4Term

Days, Periods, and Classrooms (4T) Tues1-2,Fri1-2：SCI E104

Lesson Style Lecture Lesson Style
(More Details) Face-to-face

PPT is used for lecture. Handout is delivered at each class. Original text is given at the 1st class.

Credits 2.0 Class Hours/Week 4 Language of Instruction J : Japanese

Course Level 3 : Undergraduate High-Intermediate

Course Area（Area） 26 : Biological and Life Sciences

Course Area（Discipline） 03 : Basic Biology

Eligible Students Bachelor students in the third grade

Keywords Protein chemistry, Biomolecular analysis, Drug discovery, Synchrotron, X-ray structure analysis, Bio-imaging analysis, Biophysics

Special Subject for Teacher Education 　 Special Subject 　

Class Status
within Educational
Program
(Applicable only to targeted subjects for undergraduate students) This lecture aims to give advanced knowledge on the interdisciplinary studies between chemistry and life science. Students may learn how the basic chemistry can be applied to the complicated biomolecular structure analyses.
Criterion referenced
Evaluation
(Applicable only to targeted subjects for undergraduate students) Chemistry
（Knowledge and Understanding）
・Understanding and learning advanced expertise in several chemical and interdisciplinary areas.

Class Objectives
/Class Outline Students will get the basics on various experimental methods to explore structure and function relationships of biomolecules, in particular proteins. The recent topics in protein chemistry, including protein-misfolding diseases such as Alzheimer's disease and intrinsically disordered proteins, will be given.

Class Schedule lesson1: Introduction to protein x-ray crystallography: protein chemistry in drug discovery
lesson2: The evaluation of the x-ray crystallography (R-factor, thermal factor, resolution)
lesson3: X-ray structure analysis I: Phase determination
lesson4: X-ray structure analysis II: Structure refinement
lesson5: The importance of synchrotron radiation for the protein crystallography
lesson6: Crystallizaition method of protein
lesson7: The solution structure of protein by EXAFS and SAS
lesson8: The time-resolved X-ray structure analysis (Laue method)
lesson9: Final examination (1)
lesson10: Biopolymer in live material
lesson11: Biochemical analysis: extraction of biopolymer and their detection (Basic)
lesson12: Biochemical analysis: extraction of biopolymer and their detection (Advanced)
lesson13: Cell biological analysis: Imaging the biopolymer in live (Basic microscopy)
lesson14: Cell biological analysis: Imaging the biopolymer in live (Advanced microscopy)
lesson15: Final examination (2)

Term end exam.((1) and (2)), Short quiz at each class, Assignment

Text/Reference
Books,etc. Presentation materials are available on Moodle. No additional text bookds are required.

PC or AV used in
Class,etc. Text, Handouts, Visual Materials, Microsoft Stream, moodle

(More Details) The handout at each class will be given on moodle.

Learning techniques to be incorporated Quizzes/ Quiz format, Post-class Report

Suggestions on
Preparation and
Review At each class, you are required to answer the quiz on moodle to revise what you learned.

Requirements

Grading Method Term-end exam. ((1)＆(2)50%), Short quiz (30%), Assignment (20%)

Practical Experience

Summary of Practical Experience and Class Contents based on it

Message Students are required to get to know how to use the knowledge of basic chemistry to analyze the highly complicated biomolecules.

Other From my experiences in the collaborative project with several pharmaceutical companies, I will sometimes mention to the topics on the drug discovery.

Please fill in the class improvement questionnaire which is carried out on all classes.
Instructors will reflect on your feedback and utilize the information for improving their teaching.

Academic Year	2025Year	School/Graduate School	School of Science
Lecture Code	HJ265000	Subject Classification	Specialized Education
Subject Name	生体高分子化学
Subject Name （Katakana）	セイタイコウブンシカガク
Subject Name in English	Biopolymer Chemistry
Instructor	KATAYANAGI KATSUO,YASUDA KYOTA
Instructor (Katakana)	カタヤナギ　カツオ,ヤスダ　キョウタ
Campus	Higashi-Hiroshima	Semester/Term	3rd-Year, Second Semester, 4Term
Days, Periods, and Classrooms	(4T) Tues1-2,Fri1-2：SCI E104
Lesson Style	Lecture	Lesson Style (More Details)	Face-to-face
PPT is used for lecture. Handout is delivered at each class. Original text is given at the 1st class.
Credits	2.0	Class Hours/Week	4	Language of Instruction	J : Japanese
Course Level	3 : Undergraduate High-Intermediate
Course Area（Area）	26 : Biological and Life Sciences
Course Area（Discipline）	03 : Basic Biology
Eligible Students	Bachelor students in the third grade
Keywords	Protein chemistry, Biomolecular analysis, Drug discovery, Synchrotron, X-ray structure analysis, Bio-imaging analysis, Biophysics
Special Subject for Teacher Education		Special Subject
Class Status within Educational Program (Applicable only to targeted subjects for undergraduate students)	This lecture aims to give advanced knowledge on the interdisciplinary studies between chemistry and life science. Students may learn how the basic chemistry can be applied to the complicated biomolecular structure analyses.
Criterion referenced Evaluation (Applicable only to targeted subjects for undergraduate students)	Chemistry （Knowledge and Understanding）・Understanding and learning advanced expertise in several chemical and interdisciplinary areas.
Class Objectives /Class Outline	Students will get the basics on various experimental methods to explore structure and function relationships of biomolecules, in particular proteins. The recent topics in protein chemistry, including protein-misfolding diseases such as Alzheimer's disease and intrinsically disordered proteins, will be given.
Class Schedule	lesson1: Introduction to protein x-ray crystallography: protein chemistry in drug discovery lesson2: The evaluation of the x-ray crystallography (R-factor, thermal factor, resolution) lesson3: X-ray structure analysis I: Phase determination lesson4: X-ray structure analysis II: Structure refinement lesson5: The importance of synchrotron radiation for the protein crystallography lesson6: Crystallizaition method of protein lesson7: The solution structure of protein by EXAFS and SAS lesson8: The time-resolved X-ray structure analysis (Laue method) lesson9: Final examination (1) lesson10: Biopolymer in live material lesson11: Biochemical analysis: extraction of biopolymer and their detection (Basic) lesson12: Biochemical analysis: extraction of biopolymer and their detection (Advanced) lesson13: Cell biological analysis: Imaging the biopolymer in live (Basic microscopy) lesson14: Cell biological analysis: Imaging the biopolymer in live (Advanced microscopy) lesson15: Final examination (2) Term end exam.((1) and (2)), Short quiz at each class, Assignment
Text/Reference Books,etc.	Presentation materials are available on Moodle. No additional text bookds are required.
PC or AV used in Class,etc.	Text, Handouts, Visual Materials, Microsoft Stream, moodle
(More Details)	The handout at each class will be given on moodle.
Learning techniques to be incorporated	Quizzes/ Quiz format, Post-class Report
Suggestions on Preparation and Review	At each class, you are required to answer the quiz on moodle to revise what you learned.
Requirements
Grading Method	Term-end exam. ((1)＆(2)50%), Short quiz (30%), Assignment (20%)
Practical Experience
Summary of Practical Experience and Class Contents based on it
Message	Students are required to get to know how to use the knowledge of basic chemistry to analyze the highly complicated biomolecules.
Other	From my experiences in the collaborative project with several pharmaceutical companies, I will sometimes mention to the topics on the drug discovery.
Please fill in the class improvement questionnaire which is carried out on all classes. Instructors will reflect on your feedback and utilize the information for improving their teaching.

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