Hiroshima University Syllabus

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Academic Year 2024Year School/Graduate School Graduate School of Integrated Sciences for Life (Doctoral Course)
Lecture Code WI201100 Subject Classification Specialized Education
Subject Name ゲノム編集先端研究特論A
Subject Name
Subject Name in
Trends of Genome Editing in Life Science
ノムラ ワタル,マツモト ダイスケ,スギ タクマ
Campus Across Campuses (videoconferencing, etc.) Semester/Term 1st-Year,  Second Semester,  3Term
Days, Periods, and Classrooms (3T) Tues11-12,Fri11-12:Online
Lesson Style Lecture Lesson Style
(More Details)
Online lectures using the Moodle system. Details will be emailed to students. 
Credits 2.0 Class Hours/Week   Language of Instruction B : Japanese/English
Course Level 7 : Graduate Special Studies
Course Area(Area) 26 : Biological and Life Sciences
Course Area(Discipline) 03 : Basic Biology
Eligible Students Doctor's students in the Frontier Development Program for Genome Editing
Keywords SDG_03, SDG_09 
Special Subject for Teacher Education   Special Subject  
Class Status
within Educational
(Applicable only to targeted subjects for undergraduate students)
Criterion referenced
(Applicable only to targeted subjects for undergraduate students)
Class Objectives
/Class Outline
Teachures who are specialists of genome editing technology will give lectures on advanced technologies related to genome editing and explain their principles and application examples. Students will learn advanced technologies of genome editing including various CRISPR systems, transcription regulation, advanced genome editing using various effectors, CRISPR library screening, chromosome labeling, nucleic acid detection, recombinase technologies etc. 
Class Schedule lesson1 : Introduction of this course (Wataru Nomura)
lesson2 : Base editing technology (Hiroshi Ochiai) (Note: the order of lectures may change)
lesson3 : Utilization of next-generation sequencer in genome editing research (I)  (Hiroshi Ochiai)
lesson4 : Utilization of next-generation sequencer in genome editing research (II) (Hiroshi Ochiai)
lesson5 : Advanced tool development for TALEN and CRISPR (Daisuke Matsumoto)
lesson6 : Advanced gene knock-in technology in cultured cells (Daisuke Matsumoto)
lesson7 : Advanced technologies in gene knock-in in various animals and their applied research examples (Hiroshi Ochiai)
lesson8 : Transcriptional regulation and epigenome editing technologies (Wataru Nomura)
lesson9 : CRISPR library screening (Hiroshi Ochiai)
lesson10 : RNA editing technology using CRISPR (Hiroshi Ochiai)
lesson11 : Advanced technology of labeling specific genomic loci (Hiroshi Ochiai)
lesson12 : Chromosome reorganization technology using genome editing (Hiroshi Ochiai)
lesson13 : ZFN technology (Wataru Nomura)
lesson14 : Recombinase technology (Wataru Nomura)
lesson15 : Structural biology of genome editing (Takuma Sugi) 
No particular textbook. 
PC or AV used in
(More Details) Moodle system, handout 
Learning techniques to be incorporated  
Suggestions on
Preparation and
Instructors will give instructions about preparation and review as needed. 
Grading Method The final grade is formed as a weighed sum of small exams mark and reports. 
Practical Experience  
Summary of Practical Experience and Class Contents based on it  
Please fill in the class improvement questionnaire which is carried out on all classes.
Instructors will reflect on your feedback and utilize the information for improving their teaching. 
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