TB950101 Basic Human Genetics Practice

Hiroshima University Syllabus

Japanese

Academic Year 2024Year School/Graduate School Graduate School of Biomedical and Health Sciences (Master’s Course)

Lecture Code TB950101 Subject Classification Specialized Education

Subject Name 基礎人類遺伝学演習

Subject Name
（Katakana）キソジンルイイデンガクエンシュウ

Subject Name in
English Basic Human Genetics Practice

Instructor HINOI TAKAO,HIYAMA EISO,MARUYAMA HIROFUMI,OKADA SATOSHI

Instructor
(Katakana) ヒノイ　タカオ,ヒヤマ　エイソウ,マルヤマ　ヒロフミ,オカダ　サトシ

Campus Kasumi Semester/Term 1st-Year, First Semester, First Semester

Days, Periods, and Classrooms (1st) Inte

Lesson Style Seminar Lesson Style
(More Details) 　

Lecture-centered, exercise-centered, heavy use of board, discussion, student presentations, field practice, work, use of chemicals

Credits 1.0 Class Hours/Week 　 Language of Instruction B : Japanese／English

Course Level 5 : Graduate Basic

Course Area（Area） 26 : Biological and Life Sciences

Course Area（Discipline） 04 : Life Sciences

Eligible Students

Keywords Students will be able to calculate theoretical recurrence rates based on family tree creation. Students will be able to explain genetic medicine analysis methods to clients in an easy-to-understand manner.

Special Subject for Teacher Education 　 Special Subject 　

Class Status
within Educational
Program
(Applicable only to targeted subjects for undergraduate students)
Criterion referenced
Evaluation
(Applicable only to targeted subjects for undergraduate students)

Class Objectives
/Class Outline Students will be able to calculate theoretical recurrence rates based on family tree creation. Students will be able to explain genetic medicine analysis methods to clients in an easy-to-understand manner.

Class Schedule lesson1 Online search methods for genetic medical information, collection of genetic information and genealogical materials, and genealogy
lesson2 Molecular and biochemical mechanisms of hereditary diseases, genetic mutation description methods
lesson3 Fundamentals of cytogenetics: cell division, chromosomes, chromosome aberrations, clinical chromosome aberrations
lesson4 Genetic and biochemical analysis methods, karyotyping methods（ISCN2016）
lesson5 DNA polymorphism and linkage analysis, SNPs and association analysis: haplotypes, linkage disequilibrium
lesson6 Theoretical recurrence rate estimates: autosomal dominant, autosomal recessive, X-linked recessive and dominant inheritance
lesson7 Estimation of empirical recurrence rates: chromosomal aberrations and multifactorial inheritance
lesson8 Reproductive medicine
lesson9 Introduction to Preimplantation Diagnosis
lesson10 Introduction to Prenatal Diagnosis
lesson11 Introduction ofto IRUD (Initiative of Rare and Undiagnosed Disease Initiative)
lesson12 Advanced medicine such as gene therapy and transplantation therapy
lesson13 Pharmacogenetics and Pharmacogenomics
lesson14 Introduction to Cancer Genome Medicine Assessment of somatic mutations, Assessment and Response to Germline Mutations
lesson15 Introduction to Bioinformatics Narrowing down harmful mutations

Text/Reference
Books,etc. Yoshimitsu Fukushima (Translator), Thompson & Thompson Genetic Medicine, 2nd Edition, (2017) Medical Science International
Yoshimitsu Fukushima (Supervisor), Akihiro Sakurai (Editor), Genetic Counseling Manual Revised 3rd Edition, (2016) Nankendo
Masami Muramatsu (Supervisor, Translation), Ryo Kominami (Supervisor, Translation), Takehiko Sasazuki (Translation), Shoji Tsuji (Translation), Human Molecular Genetics 4th Edition, (2011) Medical Science International
R.J.McKINLAY GARDNER,,CHROMOSOME ABNORMALITIES AND GENETIC COUNSERING,5th ed.

PC or AV used in
Class,etc. 　

(More Details)

Learning techniques to be incorporated 　

Suggestions on
Preparation and
Review Specific instructions will be given in each class.

Requirements None

Grading Method Judgment will be made on the basis of class attitude and assignment reports.

Practical Experience

Summary of Practical Experience and Class Contents based on it

Message

Other

Please fill in the class improvement questionnaire which is carried out on all classes.
Instructors will reflect on your feedback and utilize the information for improving their teaching.

Academic Year	2024Year	School/Graduate School	Graduate School of Biomedical and Health Sciences (Master’s Course)
Lecture Code	TB950101	Subject Classification	Specialized Education
Subject Name	基礎人類遺伝学演習
Subject Name （Katakana）	キソジンルイイデンガクエンシュウ
Subject Name in English	Basic Human Genetics Practice
Instructor	HINOI TAKAO,HIYAMA EISO,MARUYAMA HIROFUMI,OKADA SATOSHI
Instructor (Katakana)	ヒノイ　タカオ,ヒヤマ　エイソウ,マルヤマ　ヒロフミ,オカダ　サトシ
Campus	Kasumi	Semester/Term	1st-Year, First Semester, First Semester
Days, Periods, and Classrooms	(1st) Inte
Lesson Style	Seminar	Lesson Style (More Details)
Lecture-centered, exercise-centered, heavy use of board, discussion, student presentations, field practice, work, use of chemicals
Credits	1.0	Class Hours/Week		Language of Instruction	B : Japanese／English
Course Level	5 : Graduate Basic
Course Area（Area）	26 : Biological and Life Sciences
Course Area（Discipline）	04 : Life Sciences
Eligible Students
Keywords	Students will be able to calculate theoretical recurrence rates based on family tree creation. Students will be able to explain genetic medicine analysis methods to clients in an easy-to-understand manner.
Special Subject for Teacher Education		Special Subject
Class Status within Educational Program (Applicable only to targeted subjects for undergraduate students)
Criterion referenced Evaluation (Applicable only to targeted subjects for undergraduate students)
Class Objectives /Class Outline	Students will be able to calculate theoretical recurrence rates based on family tree creation. Students will be able to explain genetic medicine analysis methods to clients in an easy-to-understand manner.
Class Schedule	lesson1 Online search methods for genetic medical information, collection of genetic information and genealogical materials, and genealogy lesson2 Molecular and biochemical mechanisms of hereditary diseases, genetic mutation description methods lesson3 Fundamentals of cytogenetics: cell division, chromosomes, chromosome aberrations, clinical chromosome aberrations lesson4 Genetic and biochemical analysis methods, karyotyping methods（ISCN2016） lesson5 DNA polymorphism and linkage analysis, SNPs and association analysis: haplotypes, linkage disequilibrium lesson6 Theoretical recurrence rate estimates: autosomal dominant, autosomal recessive, X-linked recessive and dominant inheritance lesson7 Estimation of empirical recurrence rates: chromosomal aberrations and multifactorial inheritance lesson8 Reproductive medicine lesson9 Introduction to Preimplantation Diagnosis lesson10 Introduction to Prenatal Diagnosis lesson11 Introduction ofto IRUD (Initiative of Rare and Undiagnosed Disease Initiative) lesson12 Advanced medicine such as gene therapy and transplantation therapy lesson13 Pharmacogenetics and Pharmacogenomics lesson14 Introduction to Cancer Genome Medicine Assessment of somatic mutations, Assessment and Response to Germline Mutations lesson15 Introduction to Bioinformatics Narrowing down harmful mutations
Text/Reference Books,etc.	Yoshimitsu Fukushima (Translator), Thompson & Thompson Genetic Medicine, 2nd Edition, (2017) Medical Science International Yoshimitsu Fukushima (Supervisor), Akihiro Sakurai (Editor), Genetic Counseling Manual Revised 3rd Edition, (2016) Nankendo Masami Muramatsu (Supervisor, Translation), Ryo Kominami (Supervisor, Translation), Takehiko Sasazuki (Translation), Shoji Tsuji (Translation), Human Molecular Genetics 4th Edition, (2011) Medical Science International R.J.McKINLAY GARDNER,,CHROMOSOME ABNORMALITIES AND GENETIC COUNSERING,5th ed.
PC or AV used in Class,etc.
(More Details)
Learning techniques to be incorporated
Suggestions on Preparation and Review	Specific instructions will be given in each class.
Requirements	None
Grading Method	Judgment will be made on the basis of class attitude and assignment reports.
Practical Experience
Summary of Practical Experience and Class Contents based on it
Message
Other
Please fill in the class improvement questionnaire which is carried out on all classes. Instructors will reflect on your feedback and utilize the information for improving their teaching.

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