I7085001 Biophysical Chemistry

Hiroshima University Syllabus

Japanese

Academic Year 2024Year School/Graduate School School of Pharmaceutical Sciences Program of Pharmaceutical Sciences

Lecture Code I7085001 Subject Classification Specialized Education

Subject Name 生物物理化学

Subject Name
（Katakana）セイブツブツリカガク

Subject Name in
English Biophysical Chemistry

Instructor KINOSHITA EMIKO,NAGASE KENICHI

Instructor
(Katakana) キノシタ　エミコ,ナガセ　ケンイチ

Campus Kasumi Semester/Term 3rd-Year, First Semester, 2Term

Days, Periods, and Classrooms (2T) Tues1-4：PHS Lecture Rm 2

Lesson Style Lecture Lesson Style
(More Details) 　

Lecture, Discussion, Presentation

Credits 2.0 Class Hours/Week 　 Language of Instruction B : Japanese／English

Course Level 4 : Undergraduate Advanced

Course Area（Area） 27 : Health Sciences

Course Area（Discipline） 03 : Pharmaceutical Sciences

Eligible Students

Keywords

Special Subject for Teacher Education 　 Special Subject 　

Class Status
within Educational
Program
(Applicable only to targeted subjects for undergraduate students)
Criterion referenced
Evaluation
(Applicable only to targeted subjects for undergraduate students) Pharmaceutical Sciences
（Knowledge and Understanding）
・The basic knowledge and understanding of basic structures, physical characters and reaction of medicine and other inorganic and organic compounds. ●quality ⑤

Medicinal Sciences
（Knowledge and Understanding）
・The knowledge of chemical compounds including medicine.
・The knowledge relating to mutual reaction between chemical compounds including medicine and a human body
（Abilities and Skills）
・Development of knowledge relating to mutual reaction between chemical compounds including medicine and a human body (application)

Class Objectives
/Class Outline We understand the phenomena involved in physical chemistry, such as membrane transports of small biomolecules in our body and their thermodynamic and electrical changes and learn the ability that we can explain them.

Class Schedule Lesson 1
Physicochemical property of the water solution (body fluid) 1 (Water & solution, thermal capacity, thermal conductivity, heat of fusion, the heat of evaporation, surface tension, dissolution ability etc.)
Lesson 2
Physichemical properties of the water solution (body fluid) 2 (osmotic pressure, molar concentration and osmolar density, colloid osmotic pressure)
Lesson 3
Physichemical properties of the water solution (body fluid) 3 (pH & acid-base equilibrium, pH buffer solution & buffering ability, in vivo buffer action)
Lesson 4
Biomembrane structure theory 1 (Physicochemical property of membrane lipids)
Lesson 5
Biomembrane structure theory 2 (membrane theory, unit membrane model, fluid mosaic model, lipid bilayer, membrane fluidity)
Lesson 6
Biomembrane structure theory 3 (Structural theory of membrane proteins)
Lesson 7
The 1st group presentation and panel discussion
Lesson 8
Midterm test
Lesson 9
In vivo electric chemistry 1 (classification of the small molecule membrane transport)
Lesson 10
In vivo electric chemistry 2 (Thermodynamics of membrane transport, membrane potential & Nernst equation)
Lesson 11
In vivo electric chemistry 3 (Transmission and transduction in excitation, membrane topology of ion channels)
Lesson 12
Secretion and absorption (mechanisms of filtration and reabsorption, active adjustment mechanism of quantity of body fluid and the blood pressure)
Lesson 13
Pharmaceutical products and biological toxins which target on high-molecular-mass proteins
lesson14
Pathogenic diseases due to dysfunctions of high-molecular-mass proteins
Lesson 15
The 2nd group discussion and panel discussion
Lesson 16
End-of-term test

Midterm and end-of-term tests
Group presentations and panel discussions

Text/Reference
Books,etc. Distribute an original text during a lecture

PC or AV used in
Class,etc. 　

(More Details) Distribution documents and pictures by PC

Learning techniques to be incorporated 　

Suggestions on
Preparation and
Review Careful reading of the distribution documents
Repeated practice of the exercises in the original text

Requirements

Grading Method The results of midterm (100 points) and end-of-term (100 points) tests (two written papers) are evaluated. To pass, 120 points or more in total are needed.
The results of group presentations and panel discussions and the percentage of attendance are also evaluated as additional points.

Practical Experience

Summary of Practical Experience and Class Contents based on it

Message

Other SBOs: C1-(1)-①-1～3, C1-(1)-②-1～7, C1-(1)-③-1～6, C1-(2)-①-1～3, C1-(2)-②-1～7, C1-(2)-③-1～5, C1-(2)-④-1～4, C1-(2)-⑤-1～3, C1-(2)-⑥-1～4, C1-(2)-⑦-1～2, C1-(3)-①-1～7, C2-(2)-①-1～4, C2-(2)-②-1～4, C2-(6)-②-2, C4-(1)-①-1～2, C4-(1)-②-2～4, C4-(2)-①-1～2, C4-(2)-④-1～2, C4-(3)-①-1, C4-(3)-⑦-1, C6-(1)-①-1, C6-(1)-③-1, C6-(2)-①-1, C6-(2)-④-1, C6-(3)-①-1, C6-(3)-②-1～2, C6-(3)-③-1～4, C6-(3)-④-1-2, C6-(6)-①-1, C6-(6)-②-1, C6-(6)-③-1

Please fill in the class improvement questionnaire which is carried out on all classes.
Instructors will reflect on your feedback and utilize the information for improving their teaching.

Academic Year	2024Year	School/Graduate School	School of Pharmaceutical Sciences Program of Pharmaceutical Sciences
Lecture Code	I7085001	Subject Classification	Specialized Education
Subject Name	生物物理化学
Subject Name （Katakana）	セイブツブツリカガク
Subject Name in English	Biophysical Chemistry
Instructor	KINOSHITA EMIKO,NAGASE KENICHI
Instructor (Katakana)	キノシタ　エミコ,ナガセ　ケンイチ
Campus	Kasumi	Semester/Term	3rd-Year, First Semester, 2Term
Days, Periods, and Classrooms	(2T) Tues1-4：PHS Lecture Rm 2
Lesson Style	Lecture	Lesson Style (More Details)
Lecture, Discussion, Presentation
Credits	2.0	Class Hours/Week		Language of Instruction	B : Japanese／English
Course Level	4 : Undergraduate Advanced
Course Area（Area）	27 : Health Sciences
Course Area（Discipline）	03 : Pharmaceutical Sciences
Eligible Students
Keywords
Special Subject for Teacher Education		Special Subject
Class Status within Educational Program (Applicable only to targeted subjects for undergraduate students)
Criterion referenced Evaluation (Applicable only to targeted subjects for undergraduate students)	Pharmaceutical Sciences （Knowledge and Understanding）・The basic knowledge and understanding of basic structures, physical characters and reaction of medicine and other inorganic and organic compounds. ●quality ⑤ Medicinal Sciences （Knowledge and Understanding）・The knowledge of chemical compounds including medicine. ・The knowledge relating to mutual reaction between chemical compounds including medicine and a human body （Abilities and Skills）・Development of knowledge relating to mutual reaction between chemical compounds including medicine and a human body (application)
Class Objectives /Class Outline	We understand the phenomena involved in physical chemistry, such as membrane transports of small biomolecules in our body and their thermodynamic and electrical changes and learn the ability that we can explain them.
Class Schedule	Lesson 1 Physicochemical property of the water solution (body fluid) 1 (Water & solution, thermal capacity, thermal conductivity, heat of fusion, the heat of evaporation, surface tension, dissolution ability etc.) Lesson 2 Physichemical properties of the water solution (body fluid) 2 (osmotic pressure, molar concentration and osmolar density, colloid osmotic pressure) Lesson 3 Physichemical properties of the water solution (body fluid) 3 (pH & acid-base equilibrium, pH buffer solution & buffering ability, in vivo buffer action) Lesson 4 Biomembrane structure theory 1 (Physicochemical property of membrane lipids) Lesson 5 Biomembrane structure theory 2 (membrane theory, unit membrane model, fluid mosaic model, lipid bilayer, membrane fluidity) Lesson 6 Biomembrane structure theory 3 (Structural theory of membrane proteins) Lesson 7 The 1st group presentation and panel discussion Lesson 8 Midterm test Lesson 9 In vivo electric chemistry 1 (classification of the small molecule membrane transport) Lesson 10 In vivo electric chemistry 2 (Thermodynamics of membrane transport, membrane potential & Nernst equation) Lesson 11 In vivo electric chemistry 3 (Transmission and transduction in excitation, membrane topology of ion channels) Lesson 12 Secretion and absorption (mechanisms of filtration and reabsorption, active adjustment mechanism of quantity of body fluid and the blood pressure) Lesson 13 Pharmaceutical products and biological toxins which target on high-molecular-mass proteins lesson14 Pathogenic diseases due to dysfunctions of high-molecular-mass proteins Lesson 15 The 2nd group discussion and panel discussion Lesson 16 End-of-term test Midterm and end-of-term tests Group presentations and panel discussions
Text/Reference Books,etc.	Distribute an original text during a lecture
PC or AV used in Class,etc.
(More Details)	Distribution documents and pictures by PC
Learning techniques to be incorporated
Suggestions on Preparation and Review	Careful reading of the distribution documents Repeated practice of the exercises in the original text
Requirements
Grading Method	The results of midterm (100 points) and end-of-term (100 points) tests (two written papers) are evaluated. To pass, 120 points or more in total are needed. The results of group presentations and panel discussions and the percentage of attendance are also evaluated as additional points.
Practical Experience
Summary of Practical Experience and Class Contents based on it
Message
Other	SBOs: C1-(1)-①-1～3, C1-(1)-②-1～7, C1-(1)-③-1～6, C1-(2)-①-1～3, C1-(2)-②-1～7, C1-(2)-③-1～5, C1-(2)-④-1～4, C1-(2)-⑤-1～3, C1-(2)-⑥-1～4, C1-(2)-⑦-1～2, C1-(3)-①-1～7, C2-(2)-①-1～4, C2-(2)-②-1～4, C2-(6)-②-2, C4-(1)-①-1～2, C4-(1)-②-2～4, C4-(2)-①-1～2, C4-(2)-④-1～2, C4-(3)-①-1, C4-(3)-⑦-1, C6-(1)-①-1, C6-(1)-③-1, C6-(2)-①-1, C6-(2)-④-1, C6-(3)-①-1, C6-(3)-②-1～2, C6-(3)-③-1～4, C6-(3)-④-1-2, C6-(6)-①-1, C6-(6)-②-1, C6-(6)-③-1
Please fill in the class improvement questionnaire which is carried out on all classes. Instructors will reflect on your feedback and utilize the information for improving their teaching.

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