Hiroshima University Syllabus

Back to syllabus main page
Academic Year 2024Year School/Graduate School School of Pharmaceutical Sciences Program of Pharmaceutical Sciences
Lecture Code I7085001 Subject Classification Specialized Education
Subject Name 生物物理化学
Subject Name
Subject Name in
Biophysical Chemistry
キノシタ エミコ,ナガセ ケンイチ
Campus Kasumi Semester/Term 3rd-Year,  First Semester,  2Term
Days, Periods, and Classrooms (2T) Tues1-4:PHS Lecture Rm 2
Lesson Style Lecture Lesson Style
(More Details)
Lecture, Discussion, Presentation 
Credits 2.0 Class Hours/Week   Language of Instruction B : Japanese/English
Course Level 4 : Undergraduate Advanced
Course Area(Area) 27 : Health Sciences
Course Area(Discipline) 03 : Pharmaceutical Sciences
Eligible Students
Special Subject for Teacher Education   Special Subject  
Class Status
within Educational
(Applicable only to targeted subjects for undergraduate students)
Criterion referenced
(Applicable only to targeted subjects for undergraduate students)
Pharmaceutical Sciences
(Knowledge and Understanding)
・The basic knowledge and understanding of basic structures, physical characters and reaction of medicine and other inorganic and organic compounds. ●quality ⑤

Medicinal Sciences
(Knowledge and Understanding)
・The knowledge of chemical compounds including medicine.
・The knowledge relating to mutual reaction between chemical compounds including medicine and a human body
(Abilities and Skills)
・Development of knowledge relating to mutual reaction between chemical compounds including medicine and a human body (application) 
Class Objectives
/Class Outline
We understand the phenomena involved in  physical chemistry,  such as membrane transports of small biomolecules in our body and their  thermodynamic and electrical changes and learn the ability that we can explain them. 
Class Schedule Lesson 1
Physicochemical property of the water solution (body fluid) 1 (Water & solution, thermal capacity, thermal conductivity, heat of fusion, the heat of evaporation, surface tension, dissolution ability etc.)
Lesson 2
Physichemical properties of the water solution (body fluid) 2 (osmotic pressure, molar concentration and osmolar density, colloid osmotic pressure)
Lesson 3
Physichemical properties of the water solution (body fluid) 3 (pH & acid-base equilibrium, pH buffer solution & buffering ability, in vivo buffer action)
Lesson 4
Biomembrane structure theory 1 (Physicochemical property of membrane lipids)
Lesson 5
Biomembrane structure theory 2 (membrane theory, unit membrane model, fluid mosaic model, lipid bilayer, membrane fluidity)
Lesson 6
Biomembrane structure theory 3 (Structural theory of membrane proteins)
Lesson 7
The 1st group presentation and panel discussion
Lesson 8
Midterm test
Lesson 9
In vivo electric chemistry 1 (classification of the small molecule membrane transport)
Lesson 10
In vivo electric chemistry 2 (Thermodynamics of membrane transport, membrane potential & Nernst equation)
Lesson 11
In vivo electric chemistry 3 (Transmission and transduction in excitation, membrane topology of ion channels)
Lesson 12
Secretion and absorption (mechanisms of filtration and reabsorption, active adjustment mechanism of quantity of body fluid and the blood pressure)
Lesson 13
Pharmaceutical products and biological toxins which target on high-molecular-mass proteins
Pathogenic diseases due to dysfunctions of high-molecular-mass proteins
Lesson 15
The 2nd group discussion and panel discussion
Lesson 16
End-of-term test

Midterm and end-of-term tests
Group presentations and panel discussions 
Distribute an original text during a lecture 
PC or AV used in
(More Details) Distribution documents and pictures by PC 
Learning techniques to be incorporated  
Suggestions on
Preparation and
Careful reading of the distribution documents
Repeated practice of the exercises in the original text 
Grading Method The results of midterm (100 points) and end-of-term (100 points) tests (two written papers) are evaluated. To pass, 120 points or more in total are needed.
The results of group presentations and panel discussions and the percentage of attendance are also evaluated as additional points. 
Practical Experience  
Summary of Practical Experience and Class Contents based on it  
Other SBOs: C1-(1)-①-1~3, C1-(1)-②-1~7, C1-(1)-③-1~6, C1-(2)-①-1~3, C1-(2)-②-1~7, C1-(2)-③-1~5, C1-(2)-④-1~4, C1-(2)-⑤-1~3, C1-(2)-⑥-1~4, C1-(2)-⑦-1~2, C1-(3)-①-1~7, C2-(2)-①-1~4, C2-(2)-②-1~4, C2-(6)-②-2, C4-(1)-①-1~2, C4-(1)-②-2~4, C4-(2)-①-1~2, C4-(2)-④-1~2, C4-(3)-①-1, C4-(3)-⑦-1, C6-(1)-①-1, C6-(1)-③-1, C6-(2)-①-1, C6-(2)-④-1, C6-(3)-①-1, C6-(3)-②-1~2, C6-(3)-③-1~4, C6-(3)-④-1-2, C6-(6)-①-1, C6-(6)-②-1, C6-(6)-③-1  
Please fill in the class improvement questionnaire which is carried out on all classes.
Instructors will reflect on your feedback and utilize the information for improving their teaching. 
Back to syllabus main page