| Academic Year |
2024Year |
School/Graduate School |
School of Pharmaceutical Sciences Program of Pharmaceutical Sciences |
| Lecture Code |
I7025001 |
Subject Classification |
Specialized Education |
| Subject Name |
天然物薬品構造化学 |
Subject Name
（Katakana） |
テンネンブツヤクヒンコウゾウカガク |
Subject Name in
English |
Natural Products Chemistry |
| Instructor |
MATSUNAMI KATSUYOSHI |
Instructor
(Katakana) |
マツナミ カツヨシ |
| Campus |
Kasumi |
Semester/Term |
2nd-Year, First Semester, 1Term |
| Days, Periods, and Classrooms |
(1T) Weds1-4：霞R404講義室 |
| Lesson Style |
Lecture |
Lesson Style
(More Details) |
|
| Lecture (power point slide, writing on the blackboard, quiz) |
| Credits |
2.0 |
Class Hours/Week |
|
Language of Instruction |
B
:
Japanese／English |
| Course Level |
2
:
Undergraduate Low-Intermediate
|
| Course Area（Area） |
27
:
Health Sciences |
| Course Area（Discipline） |
03
:
Pharmaceutical Sciences |
| Eligible Students |
2nd year student |
| Keywords |
SDG_03, SDG_04, Natural products chemistry, biosynthesis, polyketide, phenylpropanoid, lignan, flavonoid, terpene
Spectral analysis, chemical structure, IR, UV, MS, NMR |
| Special Subject for Teacher Education |
|
Special Subject |
|
Class Status
within Educational
Program
(Applicable only to targeted subjects for undergraduate students) | |
|---|
Criterion referenced
Evaluation
(Applicable only to targeted subjects for undergraduate students) | Pharmaceutical Sciences
（Knowledge and Understanding）
・The basic knowledge and understanding of basic structures, physical characters and reaction of medicine and other inorganic and organic compounds. ●quality ⑤
Medicinal Sciences
（Knowledge and Understanding）
・The knowledge of chemical compounds including medicine. |
|---|
Class Objectives
/Class Outline |
To learn
(1) how to solve the chemical structures by spectroscopic method.
(2) plant origins, biosynthetic pathway, and pharmacological activity of various natural products. |
| Class Schedule |
lesson1 Infrared (IR) and Ultraviolet-Visible (UV-VIS) spectroscopy
lesson2 Mass spectroscopy (MS)
lesson3 1H NMR (proton Nuclear Magnetic Resonance) spectroscopy
lesson4 13C NMR (carbon Nuclear Magnetic Resonance) spectroscopy
lesson5 2D(two dimentional)-NMR spectroscopy
lesson6 Structural analysis
lesson7 Midterm exam (Structural analysis by spectroscopy)
lesson8 Fundamental biosynthetic pathways
lesson9 Acetate malonate pathway for polyketide biosynthesis
lesson10 Shikimic acid pathway for phenylpropanoid biosyhthesis
lesson11 Biosynthesis of lignan related compounds
lesson12 Biosynthesis of flavonoids and tannins
lesson13 Mevalonate and non-mevalonate pathways
lesson14 Mono-, sesqui-, di-, sester-, tri- and tetraterpenes
lesson15 Final exam (Natural products chemistry)
Mid-term, final exam, and quiz |
Text/Reference
Books,etc. |
Partner Natural products chemistry (Nankodo) |
PC or AV used in
Class,etc. |
|
| (More Details) |
Text, slide presentation, and writing on the blackboard |
| Learning techniques to be incorporated |
|
Suggestions on
Preparation and
Review |
Review the lecture with the textbook |
| Requirements |
|
| Grading Method |
Midterm exam (40) , final exam (40), quiz (20)
Criterion for passing: ≧60 |
| Practical Experience |
|
| Summary of Practical Experience and Class Contents based on it |
|
| Message |
Questions are welcomed at any time via email or in person. However, in the case of in-person meetings, prior contact via email is preferred. |
| Other |
References: Medicinal Natural Products (Paul M Dewick, John Wiley & Sons, Ltd.)
Spectrometric Identification of Organic Compounds (Robert M. Silverstein et al., John Wiley & Sons, Ltd.)
Organic Chemistry: Structure and Function (K. Peter C. Vollhardt, Neil E. Shore, WH Freeman)
In this course, students will master the content of the following SBOs.
C2-(4)-①-1, C2-(4)-①-2, C2-(4)-①-3, C2-(4)-①-4, C2-(4)-①-5, C2-(4)-①-6, C2-(4)-②-1, C2-(4)-③-1, C2-(5)-①-1, C2-(5)-①-2, C2-(5)-①-3, C2-(5)-①-4, C3-(4)-①-1, C3-(4)-①-2, C3-(4)-①-3, C3-(4)-①-4, C3-(4)-①-5, C3-(4)-②-1, C3-(4)-②-2, C3-(4)-③-1, C3-(4)-③-2, C3-(4)-③-3, C3-(4)-③-4, C3-(4)-④-1, C5-(1)-①-1, C5-(1)-①-2, C5-(1)-①-3, C5-(1)-①-4, C5-(1)-②-1, C5-(1)-③-1, C5-(1)-③-2, C5-(2)-①-1, C5-(2)-①-2, C5-(2)-①-3, C5-(2)-①-4, C5-(2)-①-5, C5-(2)-②-1, C5-(2)-②-2, C5-(2)-③-1, C5-(2)-④-1, C5-(2)-④-2, C5-(2)-④-3 |
Please fill in the class improvement questionnaire which is carried out on all classes.
Instructors will reflect on your feedback and utilize the information for improving their teaching. |