I7021001 Nuclear Pharmacy

Hiroshima University Syllabus

Japanese

Academic Year 2024Year School/Graduate School School of Pharmaceutical Sciences Program of Pharmaceutical Sciences

Lecture Code I7021001 Subject Classification Specialized Education

Subject Name 放射化学・放射線保健学

Subject Name
（Katakana）ホウシャセンカガク・ホウシャセンホケンガク

Subject Name in
English Nuclear Pharmacy

Instructor OZAWA KOICHIRO,SASATANI MEGUMI

Instructor
(Katakana) オザワ　コウイチロウ,ササタニ　メグミ

Campus Kasumi Semester/Term 2nd-Year,  First Semester,  1Term

Days, Periods, and Classrooms (1T) Fri5-8：PHS Lecture Rm 2

Lesson Style Lecture Lesson Style
(More Details) 　

Lecture and using blackboard and OHP projector

Credits 2.0 Class Hours/Week 　 Language of Instruction B : Japanese／English

Course Level 4 : Undergraduate Advanced

Course Area（Area） 27 : Health Sciences

Course Area（Discipline） 03 : Pharmaceutical Sciences

Eligible Students second-year undergraduates of Pharmaceutical sciences

Keywords SDG_03 SDG_12 radioisotope，physical property，measuring methods，administration and laws，Application to medical care，radiopharmaceutical,Practical work experience, cancer, human health

Special Subject for Teacher Education 　 Special Subject 　

Class Status
within Educational
Program
(Applicable only to targeted subjects for undergraduate students)
Criterion referenced
Evaluation
(Applicable only to targeted subjects for undergraduate students) Pharmaceutical Sciences
（Knowledge and Understanding）
・The basic knowledge and understanding of basic structures, physical characters and reaction of medicine and other inorganic and organic compounds. ●quality ⑤
（Abilities and Skills）
・To be able to handle major analysis methods written in the Japanese Pharmacopoeia. ●quality ⑤
（Comprehensive Abilities）
・The research ability: the ability to select issues to be solved in the professional field of pharmacist and carry out measures and research to solve the issues.  ●quality ⑧

Medicinal Sciences
（Knowledge and Understanding）
・The knowledge of chemical compounds including medicine.

Class Objectives
/Class Outline GIO：To explain structure and the emission disintegration of the atom. To  list up kinds of the ionizing radiation and to explain the interaction with those materials. To explain the physical property of a representative radionuclide.  To explain nuclear reaction and radioactive equilibrium. To explain the principle of measurement of the radiation. To explain a property and a use of representative radiopharmaceutical.
Summary of the class：To learn radioisotope, physical property，measuring methods，administration and laws，Application to medical care，and radiopharmaceutical.

Class Schedule lesson1
Physics of the radioisotope
Atomic nucleus, Elementary particle, Interaction, Nuclear force, Stability, Binding energy, Mass defect, Half-life, the mass law of the conservation of energy, Alpha decay, Beta decay, Gamma decay, the origin of the radioisotope
(Ozawa)
lesson2
Interaction with a radiation and the material（１）
Radiation, Decay scheme, dispersion, ionization, excitation, bremsstrahlung
(Ozawa)
lesson3
第3回　Interaction with a radiation and the material（２）
annihilation gamma ray，photoelectric effect，Compton scattering，Pair electron production，Shielding effect
(Ozawa)
lesson4
The measurement of the radiation（１）
Ionization chamber，Proportional counter
(Ozawa)
lesson5
The measurement of the radiation（２）
Geiger-Muller tube，Semiconductor detector，scintillation detector
(Ozawa)
lesson6
The measurement of the radiation（３）
autoradiography，pocket chamber，Other method for measurement，Unit of radiation
(Ozawa)
lesson7
Radiation chemistry
Radiological generation，Synthesis of radioactive compound，Characteristic of the tracer material，radiochemical analysis
(Ozawa)
lesson 8
Radiobiology（１）
Target molecules，Damage and restoration of DNA，cell and tissue disorder，acute radiation syndrome，Critical Organ，Efficiency Half Life，Threshold，Late effect，Stochastic effects，Deterministic effects
(Ozawa)
lesson 9
Radiobiology（２）
Carcinogenesis，hereditary effects，Background radiation
(Ozawa)
lesson 10
Safe handling of the radiation（１）
Safe handling of sealed radioactive material, Safe handling of unsealed radioactive material, Radiation exposure, ，Shielding，Safety management，Protection from radiation exposure, Dose management，Physical examination，Radioactive waste
(Ozawa)
lesson 11
Safe handling of the radiation（２）
Laws and restrictions
(Ozawa)
lesson 12
Uses of the radiation（１）
Application in the pharmacy research field，Tracer experiment
(Ozawa)
lesson 13
Uses of the radiation（２）
Radiopharmaceuticals and application to clinical medicine
(Ozawa)
lesson 14
Genome damage by radiation exposure and its repair mechanisms；Genome damage by radiation and non-ionizing radiation, damage repair mechanisms, genetic diseases
(Sasatani)
lesson 15
Mechanism of carcinogenesis induced by radiation exposure；A-bomb survivors, epidemiological studies, carcinogenic risk, radiation carcinogenesis induction mechanism (initiation, promotion)
(Sasatani)

Text/Reference
Books,etc. Text：Radiochemistry and Radiopharmaceuticals（Hideo Saji, et al）Nankodou
Reference book：Resumes

PC or AV used in
Class,etc. 　

(More Details) OHP and power point

Learning techniques to be incorporated 　

Suggestions on
Preparation and
Review lesson 1 and 2: Please read Chapter 1 of the textbook and review the class.  You will take a small test in a next beginning.
lesson 3: Please read Chapter 2 of the textbook and review the class.  You will take a small test in a next beginning.
lesson 4, 5, and 6: Please read Chapter 3 of the textbook and review the class.  You will take a small test in a next beginning.
lesson 7: Please read Chapter 5 of the textbook and review the class.  You will take a small test in a next beginning.
lesson 8 and 9: Please read Chapter 9 of the textbook and review the class.  You will take a small test in a next beginning.
lesson 10 and 11: Please read Chapter 10 of the textbook and review the class.  You will take a small test in a next beginning.
lesson 12 and 13: Please read Chapter 6 of the textbook and review the class.  You will take a small test in a next beginning.
lesson 14 and 15: Please read the resume  and review the class.  You will take a small test.

Requirements

Grading Method The mid-term examination 40 points, the term examination 40 points, small tests 10 points, reports 10 points; 100 points in total.

Practical Experience Experienced

Summary of Practical Experience and Class Contents based on it A teacher who has the experience which participated in pharmacist work lectures on basic knowledge about works at a hospital and a pharmacy.

Message

Other MODEL CORE CURRICULUM FOR PHARMACY EDUCATION:C1-(1)-④-1, C1-(1)-④-2, C1-(1)-④-3, C1-(1)-④-4, C1-(1)-④-5, D2-(1)-④-1, D2-(1)-④-2, D2-(1)-④-3, D2-(1)-④-4

Please fill in the class improvement questionnaire which is carried out on all classes.
Instructors will reflect on your feedback and utilize the information for improving their teaching.

Academic Year	2024Year	School/Graduate School	School of Pharmaceutical Sciences Program of Pharmaceutical Sciences
Lecture Code	I7021001	Subject Classification	Specialized Education
Subject Name	放射化学・放射線保健学
Subject Name （Katakana）	ホウシャセンカガク・ホウシャセンホケンガク
Subject Name in English	Nuclear Pharmacy
Instructor	OZAWA KOICHIRO,SASATANI MEGUMI
Instructor (Katakana)	オザワ　コウイチロウ,ササタニ　メグミ
Campus	Kasumi	Semester/Term	2nd-Year, First Semester, 1Term
Days, Periods, and Classrooms	(1T) Fri5-8：PHS Lecture Rm 2
Lesson Style	Lecture	Lesson Style (More Details)
Lecture and using blackboard and OHP projector
Credits	2.0	Class Hours/Week		Language of Instruction	B : Japanese／English
Course Level	4 : Undergraduate Advanced
Course Area（Area）	27 : Health Sciences
Course Area（Discipline）	03 : Pharmaceutical Sciences
Eligible Students	second-year undergraduates of Pharmaceutical sciences
Keywords	SDG_03 SDG_12 radioisotope，physical property，measuring methods，administration and laws，Application to medical care，radiopharmaceutical,Practical work experience, cancer, human health
Special Subject for Teacher Education		Special Subject
Class Status within Educational Program (Applicable only to targeted subjects for undergraduate students)
Criterion referenced Evaluation (Applicable only to targeted subjects for undergraduate students)	Pharmaceutical Sciences （Knowledge and Understanding）・The basic knowledge and understanding of basic structures, physical characters and reaction of medicine and other inorganic and organic compounds. ●quality ⑤ （Abilities and Skills）・To be able to handle major analysis methods written in the Japanese Pharmacopoeia. ●quality ⑤ （Comprehensive Abilities）・The research ability: the ability to select issues to be solved in the professional field of pharmacist and carry out measures and research to solve the issues. ●quality ⑧ Medicinal Sciences （Knowledge and Understanding）・The knowledge of chemical compounds including medicine.
Class Objectives /Class Outline	GIO：To explain structure and the emission disintegration of the atom. To list up kinds of the ionizing radiation and to explain the interaction with those materials. To explain the physical property of a representative radionuclide. To explain nuclear reaction and radioactive equilibrium. To explain the principle of measurement of the radiation. To explain a property and a use of representative radiopharmaceutical. Summary of the class：To learn radioisotope, physical property，measuring methods，administration and laws，Application to medical care，and radiopharmaceutical.
Class Schedule	lesson1 Physics of the radioisotope Atomic nucleus, Elementary particle, Interaction, Nuclear force, Stability, Binding energy, Mass defect, Half-life, the mass law of the conservation of energy, Alpha decay, Beta decay, Gamma decay, the origin of the radioisotope (Ozawa) lesson2 Interaction with a radiation and the material（１） Radiation, Decay scheme, dispersion, ionization, excitation, bremsstrahlung (Ozawa) lesson3 第3回　Interaction with a radiation and the material（２） annihilation gamma ray，photoelectric effect，Compton scattering，Pair electron production，Shielding effect (Ozawa) lesson4 The measurement of the radiation（１） Ionization chamber，Proportional counter (Ozawa) lesson5 The measurement of the radiation（２） Geiger-Muller tube，Semiconductor detector，scintillation detector (Ozawa) lesson6 The measurement of the radiation（３） autoradiography，pocket chamber，Other method for measurement，Unit of radiation (Ozawa) lesson7 Radiation chemistry Radiological generation，Synthesis of radioactive compound，Characteristic of the tracer material，radiochemical analysis (Ozawa) lesson 8 Radiobiology（１） Target molecules，Damage and restoration of DNA，cell and tissue disorder，acute radiation syndrome，Critical Organ，Efficiency Half Life，Threshold，Late effect，Stochastic effects，Deterministic effects (Ozawa) lesson 9 Radiobiology（２） Carcinogenesis，hereditary effects，Background radiation (Ozawa) lesson 10 Safe handling of the radiation（１） Safe handling of sealed radioactive material, Safe handling of unsealed radioactive material, Radiation exposure, ，Shielding，Safety management，Protection from radiation exposure, Dose management，Physical examination，Radioactive waste (Ozawa) lesson 11 Safe handling of the radiation（２） Laws and restrictions (Ozawa) lesson 12 Uses of the radiation（１） Application in the pharmacy research field，Tracer experiment (Ozawa) lesson 13 Uses of the radiation（２） Radiopharmaceuticals and application to clinical medicine (Ozawa) lesson 14 Genome damage by radiation exposure and its repair mechanisms；Genome damage by radiation and non-ionizing radiation, damage repair mechanisms, genetic diseases (Sasatani) lesson 15 Mechanism of carcinogenesis induced by radiation exposure；A-bomb survivors, epidemiological studies, carcinogenic risk, radiation carcinogenesis induction mechanism (initiation, promotion) (Sasatani)
Text/Reference Books,etc.	Text：Radiochemistry and Radiopharmaceuticals（Hideo Saji, et al）Nankodou Reference book：Resumes
PC or AV used in Class,etc.
(More Details)	OHP and power point
Learning techniques to be incorporated
Suggestions on Preparation and Review	lesson 1 and 2: Please read Chapter 1 of the textbook and review the class. You will take a small test in a next beginning. lesson 3: Please read Chapter 2 of the textbook and review the class. You will take a small test in a next beginning. lesson 4, 5, and 6: Please read Chapter 3 of the textbook and review the class. You will take a small test in a next beginning. lesson 7: Please read Chapter 5 of the textbook and review the class. You will take a small test in a next beginning. lesson 8 and 9: Please read Chapter 9 of the textbook and review the class. You will take a small test in a next beginning. lesson 10 and 11: Please read Chapter 10 of the textbook and review the class. You will take a small test in a next beginning. lesson 12 and 13: Please read Chapter 6 of the textbook and review the class. You will take a small test in a next beginning. lesson 14 and 15: Please read the resume and review the class. You will take a small test.
Requirements
Grading Method	The mid-term examination 40 points, the term examination 40 points, small tests 10 points, reports 10 points; 100 points in total.
Practical Experience	Experienced
Summary of Practical Experience and Class Contents based on it	A teacher who has the experience which participated in pharmacist work lectures on basic knowledge about works at a hospital and a pharmacy.
Message
Other	MODEL CORE CURRICULUM FOR PHARMACY EDUCATION:C1-(1)-④-1, C1-(1)-④-2, C1-(1)-④-3, C1-(1)-④-4, C1-(1)-④-5, D2-(1)-④-1, D2-(1)-④-2, D2-(1)-④-3, D2-(1)-④-4
Please fill in the class improvement questionnaire which is carried out on all classes. Instructors will reflect on your feedback and utilize the information for improving their teaching.

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