Hiroshima University Syllabus

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Academic Year 2024Year School/Graduate School School of Pharmaceutical Sciences Program of Pharmaceutical Sciences
Lecture Code I7005001 Subject Classification Specialized Education
Subject Name 生化学III
Subject Name
Subject Name in
Biological Chemistry III
ニゴリカワ キヨミ
Campus Kasumi Semester/Term 2nd-Year,  First Semester,  1Term
Days, Periods, and Classrooms (1T) Tues5-8:PHS Lecture Rm 2
Lesson Style Lecture Lesson Style
(More Details)
Basically, lectures are held face-to-face.
Only the 7th lecture will be held online. 
Credits 2.0 Class Hours/Week   Language of Instruction B : Japanese/English
Course Level 2 : Undergraduate Low-Intermediate
Course Area(Area) 27 : Health Sciences
Course Area(Discipline) 03 : Pharmaceutical Sciences
Eligible Students 2nd year student, School of Pharmaceutical Sciences
Keywords Carbohydrates, Carbohydrate metabolism, SDG_03 
Special Subject for Teacher Education   Special Subject  
Class Status
within Educational
(Applicable only to targeted subjects for undergraduate students)
Criterion referenced
(Applicable only to targeted subjects for undergraduate students)
Pharmaceutical Sciences
(Knowledge and Understanding)
・Knowledge and understanding of the biological maintenance system of homeostasis and the ability to adjust to the environment  ●quality⑤

Medicinal Sciences
(Knowledge and Understanding)
・Knowledge of human and biological bodies. 
Class Objectives
/Class Outline
Students learn about the structure of carbohydrates and their role in living organisms, as well as carbohydrate metabolic pathways and their regulatory mechanisms. 
Class Schedule (1) Monosaccharides
(2) Polysaccharides
(3) Glycoconjugates
(4) Adenosine 5'-triphosphate, Phosphate group transfer potential, Redox potential
(5) Glycolysis, Fermentation
(6) Pyruvate dehydrogenase
(7) Review
(8) Mid-term exam
(9) Tricarboxylic acid cycle
(10) Carbohydrases, Metabolism of galactose, Pentose phosphate pathway
(11) Glycogenolysis, Glycogenesis, Glycogenosis
(12) Regulation of glycogen metabolism
(13) Gluconeogenesis, Oxidative phosphorylation (1)
(14) Oxidative phosphorylation (2)
(15) Final exam

There will be a quiz each time. 
Lehninger Principles of Biochemistry (W. H. Freeman and Company)
PDF files of the lecture content will be provided. 
PC or AV used in
(More Details) PDF files of the lecture content will be provided on moodle.
The quiz will be conducted on moodle 
Learning techniques to be incorporated  
Suggestions on
Preparation and
Understand following keywords.
1  Classification of carbohydrates according to the number of carbon atoms / aldose and ketose / enantiomer / Fischer projection / epimer / intramolecular hemiacetal formation / alpha and beta anomer / furanose and pyranose / Haworth projection / Systematic name of cyclic monosaccharide / amino sugar / deoxy sugar / uronic acid / aldonic acid / lactone / alditol
2  glycosidic bond / Systematic name of oligosaccharide / Storage polysaccharides, starch and glycogen / Structural polysaccharides, cellulose and chitin / Structure of amylose and cellulose / glucosaminoglycan (mucopolysaccharide) / proteoglycan / heparin
3  glycoprotein / sialic acid /oseltamivir phosphate / peptidoglycan / lysozyme
4  high-energy phosphate-containing compounds / qualitative understanding of the standard free-energy change / ATP generation via substrate-level phosphorylation / phosphoenolpyruvate / 1,3-bisphosphoglycerate / ATP generation via oxidative phosphorylation / NAD / FAD / nicotinate / riboflavin
5  synthetic pathways for high-energy phosphate-containing compounds / glycolytic enzymes / glycolytic intermediates / enzyme nomenclature (kinase, isomerase, dehydrogenase, hydratase, mutase…), energy budget of glycolysis / importance of regeneration of NAD+ / lactate fermentation / alcoholic fermentation / Roles of thiamine pyrophosphate / thiamine
6,7,10  mitochondria function / CoA and pantothenate / lipoic acid / total parenteral nutrition and TPP / importance and strategy of effective reduction of NAD and FAD / oxidative decarboxylation / TCA cycle enzymes / intermediates of TCA cycle / enzyme nomenclature (synthase, synthetase) / energy budget of TCA cycle
9,10  alpha-amylase / Sugar absorption inhibitors / UDP-glucose / galactosemia / galactitol accumulation / aldose reductase
10  production of NADPH and pentose phosphate / roles of glutathione / glucose-6-phosphate dehydrogenase deficiency
11  enzymes involved in glycogenesis and glycogenolysis / roles of glycogen in liver and muscle / glycogenosis
12  effects of glucagon and insulin / second messengers / regulation of glycogenesis and glycogenolysis
13  bypass reactions of gluconeogenesis / biotin / malate shuttle / gluconeogenesis  from lactate, glycerol and glycogenic amino acids / regulation of glycolysis and gluconeogenesis by fructose 2,6-bisphosphate
14  electron transport system / ubiquinone / cytochrome / iron-sulfur cluster / ATP synthase / chemiosmotic mechanism 
Grading Method Mid-term exam 45 points; Final exam 45 points; short tests 10 points. Total 100points.
The minimum passing grade is 60 points. 
Practical Experience  
Summary of Practical Experience and Class Contents based on it  
Other Specific Behavioral Objectives of this lecture are:
Please fill in the class improvement questionnaire which is carried out on all classes.
Instructors will reflect on your feedback and utilize the information for improving their teaching. 
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