I7005001 Biological Chemistry III

Hiroshima University Syllabus

Japanese

Academic Year 2024Year School/Graduate School School of Pharmaceutical Sciences Program of Pharmaceutical Sciences

Lecture Code I7005001 Subject Classification Specialized Education

Subject Name 生化学III

Subject Name
（Katakana）セイカガク３

Subject Name in
English Biological Chemistry III

Instructor NIGORIKAWA KIYOMI

Instructor
(Katakana) ニゴリカワ　キヨミ

Campus Kasumi Semester/Term 2nd-Year,  First Semester,  1Term

Days, Periods, and Classrooms (1T) Tues5-8：PHS Lecture Rm 2

Lesson Style Lecture Lesson Style
(More Details) 　

Basically, lectures are held face-to-face.
Only the 7th lecture will be held online.

Credits 2.0 Class Hours/Week 　 Language of Instruction B : Japanese／English

Course Level 2 : Undergraduate Low-Intermediate

Course Area（Area） 27 : Health Sciences

Course Area（Discipline） 03 : Pharmaceutical Sciences

Eligible Students 2nd year student, School of Pharmaceutical Sciences

Keywords Carbohydrates, Carbohydrate metabolism, SDG_03

Special Subject for Teacher Education 　 Special Subject 　

Class Status
within Educational
Program
(Applicable only to targeted subjects for undergraduate students)
Criterion referenced
Evaluation
(Applicable only to targeted subjects for undergraduate students) Pharmaceutical Sciences
（Knowledge and Understanding）
・Knowledge and understanding of the biological maintenance system of homeostasis and the ability to adjust to the environment  ●quality⑤

Medicinal Sciences
（Knowledge and Understanding）
・Knowledge of human and biological bodies.

Class Objectives
/Class Outline Students learn about the structure of carbohydrates and their role in living organisms, as well as carbohydrate metabolic pathways and their regulatory mechanisms.

Class Schedule (1) Monosaccharides
(2) Polysaccharides
(3) Glycoconjugates
(4) Adenosine 5'-triphosphate, Phosphate group transfer potential, Redox potential
(5) Glycolysis, Fermentation
(6) Pyruvate dehydrogenase
(7) Review
(8) Mid-term exam
(9) Tricarboxylic acid cycle
(10) Carbohydrases, Metabolism of galactose, Pentose phosphate pathway
(11) Glycogenolysis, Glycogenesis, Glycogenosis
(12) Regulation of glycogen metabolism
(13) Gluconeogenesis, Oxidative phosphorylation (1)
(14) Oxidative phosphorylation (2)
(15) Final exam

There will be a quiz each time.

Text/Reference
Books,etc. Lehninger Principles of Biochemistry (W. H. Freeman and Company)
PDF files of the lecture content will be provided.

PC or AV used in
Class,etc. 　

(More Details) PDF files of the lecture content will be provided on moodle.
The quiz will be conducted on moodle

Learning techniques to be incorporated 　

Suggestions on
Preparation and
Review Understand following keywords.
1  Classification of carbohydrates according to the number of carbon atoms / aldose and ketose / enantiomer / Fischer projection / epimer / intramolecular hemiacetal formation / alpha and beta anomer / furanose and pyranose / Haworth projection / Systematic name of cyclic monosaccharide / amino sugar / deoxy sugar / uronic acid / aldonic acid / lactone / alditol
2  glycosidic bond / Systematic name of oligosaccharide / Storage polysaccharides, starch and glycogen / Structural polysaccharides, cellulose and chitin / Structure of amylose and cellulose / glucosaminoglycan (mucopolysaccharide) / proteoglycan / heparin
3  glycoprotein / sialic acid /oseltamivir phosphate / peptidoglycan / lysozyme
4  high-energy phosphate-containing compounds / qualitative understanding of the standard free-energy change / ATP generation via substrate-level phosphorylation / phosphoenolpyruvate / 1,3-bisphosphoglycerate / ATP generation via oxidative phosphorylation / NAD / FAD / nicotinate / riboflavin
5  synthetic pathways for high-energy phosphate-containing compounds / glycolytic enzymes / glycolytic intermediates / enzyme nomenclature (kinase, isomerase, dehydrogenase, hydratase, mutase…), energy budget of glycolysis / importance of regeneration of NAD+ / lactate fermentation / alcoholic fermentation / Roles of thiamine pyrophosphate / thiamine
6,7,10  mitochondria function / CoA and pantothenate / lipoic acid / total parenteral nutrition and TPP / importance and strategy of effective reduction of NAD and FAD / oxidative decarboxylation / TCA cycle enzymes / intermediates of TCA cycle / enzyme nomenclature (synthase, synthetase) / energy budget of TCA cycle
9,10  alpha-amylase / Sugar absorption inhibitors / UDP-glucose / galactosemia / galactitol accumulation / aldose reductase
10  production of NADPH and pentose phosphate / roles of glutathione / glucose-6-phosphate dehydrogenase deficiency
11  enzymes involved in glycogenesis and glycogenolysis / roles of glycogen in liver and muscle / glycogenosis
12  effects of glucagon and insulin / second messengers / regulation of glycogenesis and glycogenolysis
13  bypass reactions of gluconeogenesis / biotin / malate shuttle / gluconeogenesis  from lactate, glycerol and glycogenic amino acids / regulation of glycolysis and gluconeogenesis by fructose 2,6-bisphosphate
14  electron transport system / ubiquinone / cytochrome / iron-sulfur cluster / ATP synthase / chemiosmotic mechanism

Requirements

Grading Method Mid-term exam 45 points; Final exam 45 points; short tests 10 points. Total 100points.
The minimum passing grade is 60 points.

Practical Experience

Summary of Practical Experience and Class Contents based on it

Message

Other Specific Behavioral Objectives of this lecture are:
【C6-(2)-②-1，C6-(2)-②-2，C6-(2)-⑥-1，C6-(5)-①-1，C6-(5)-②-1，C6-(5)-②-2，C6-(5)-②-3，C6-(5)-②-4，C6-(5)-②-5，C6-(5)-④-1，C6-(5)-④-2，C6-(5)-⑤-3】

Please fill in the class improvement questionnaire which is carried out on all classes.
Instructors will reflect on your feedback and utilize the information for improving their teaching.

Academic Year	2024Year	School/Graduate School	School of Pharmaceutical Sciences Program of Pharmaceutical Sciences
Lecture Code	I7005001	Subject Classification	Specialized Education
Subject Name	生化学III
Subject Name （Katakana）	セイカガク３
Subject Name in English	Biological Chemistry III
Instructor	NIGORIKAWA KIYOMI
Instructor (Katakana)	ニゴリカワ　キヨミ
Campus	Kasumi	Semester/Term	2nd-Year, First Semester, 1Term
Days, Periods, and Classrooms	(1T) Tues5-8：PHS Lecture Rm 2
Lesson Style	Lecture	Lesson Style (More Details)
Basically, lectures are held face-to-face. Only the 7th lecture will be held online.
Credits	2.0	Class Hours/Week		Language of Instruction	B : Japanese／English
Course Level	2 : Undergraduate Low-Intermediate
Course Area（Area）	27 : Health Sciences
Course Area（Discipline）	03 : Pharmaceutical Sciences
Eligible Students	2nd year student, School of Pharmaceutical Sciences
Keywords	Carbohydrates, Carbohydrate metabolism, SDG_03
Special Subject for Teacher Education		Special Subject
Class Status within Educational Program (Applicable only to targeted subjects for undergraduate students)
Criterion referenced Evaluation (Applicable only to targeted subjects for undergraduate students)	Pharmaceutical Sciences （Knowledge and Understanding）・Knowledge and understanding of the biological maintenance system of homeostasis and the ability to adjust to the environment ●quality⑤ Medicinal Sciences （Knowledge and Understanding）・Knowledge of human and biological bodies.
Class Objectives /Class Outline	Students learn about the structure of carbohydrates and their role in living organisms, as well as carbohydrate metabolic pathways and their regulatory mechanisms.
Class Schedule	(1) Monosaccharides (2) Polysaccharides (3) Glycoconjugates (4) Adenosine 5'-triphosphate, Phosphate group transfer potential, Redox potential (5) Glycolysis, Fermentation (6) Pyruvate dehydrogenase (7) Review (8) Mid-term exam (9) Tricarboxylic acid cycle (10) Carbohydrases, Metabolism of galactose, Pentose phosphate pathway (11) Glycogenolysis, Glycogenesis, Glycogenosis (12) Regulation of glycogen metabolism (13) Gluconeogenesis, Oxidative phosphorylation (1) (14) Oxidative phosphorylation (2) (15) Final exam There will be a quiz each time.
Text/Reference Books,etc.	Lehninger Principles of Biochemistry (W. H. Freeman and Company) PDF files of the lecture content will be provided.
PC or AV used in Class,etc.
(More Details)	PDF files of the lecture content will be provided on moodle. The quiz will be conducted on moodle
Learning techniques to be incorporated
Suggestions on Preparation and Review	Understand following keywords. 1 Classification of carbohydrates according to the number of carbon atoms / aldose and ketose / enantiomer / Fischer projection / epimer / intramolecular hemiacetal formation / alpha and beta anomer / furanose and pyranose / Haworth projection / Systematic name of cyclic monosaccharide / amino sugar / deoxy sugar / uronic acid / aldonic acid / lactone / alditol 2 glycosidic bond / Systematic name of oligosaccharide / Storage polysaccharides, starch and glycogen / Structural polysaccharides, cellulose and chitin / Structure of amylose and cellulose / glucosaminoglycan (mucopolysaccharide) / proteoglycan / heparin 3 glycoprotein / sialic acid /oseltamivir phosphate / peptidoglycan / lysozyme 4 high-energy phosphate-containing compounds / qualitative understanding of the standard free-energy change / ATP generation via substrate-level phosphorylation / phosphoenolpyruvate / 1,3-bisphosphoglycerate / ATP generation via oxidative phosphorylation / NAD / FAD / nicotinate / riboflavin 5 synthetic pathways for high-energy phosphate-containing compounds / glycolytic enzymes / glycolytic intermediates / enzyme nomenclature (kinase, isomerase, dehydrogenase, hydratase, mutase…), energy budget of glycolysis / importance of regeneration of NAD+ / lactate fermentation / alcoholic fermentation / Roles of thiamine pyrophosphate / thiamine 6,7,10 mitochondria function / CoA and pantothenate / lipoic acid / total parenteral nutrition and TPP / importance and strategy of effective reduction of NAD and FAD / oxidative decarboxylation / TCA cycle enzymes / intermediates of TCA cycle / enzyme nomenclature (synthase, synthetase) / energy budget of TCA cycle 9,10 alpha-amylase / Sugar absorption inhibitors / UDP-glucose / galactosemia / galactitol accumulation / aldose reductase 10 production of NADPH and pentose phosphate / roles of glutathione / glucose-6-phosphate dehydrogenase deficiency 11 enzymes involved in glycogenesis and glycogenolysis / roles of glycogen in liver and muscle / glycogenosis 12 effects of glucagon and insulin / second messengers / regulation of glycogenesis and glycogenolysis 13 bypass reactions of gluconeogenesis / biotin / malate shuttle / gluconeogenesis from lactate, glycerol and glycogenic amino acids / regulation of glycolysis and gluconeogenesis by fructose 2,6-bisphosphate 14 electron transport system / ubiquinone / cytochrome / iron-sulfur cluster / ATP synthase / chemiosmotic mechanism
Requirements
Grading Method	Mid-term exam 45 points; Final exam 45 points; short tests 10 points. Total 100points. The minimum passing grade is 60 points.
Practical Experience
Summary of Practical Experience and Class Contents based on it
Message
Other	Specific Behavioral Objectives of this lecture are: 【C6-(2)-②-1，C6-(2)-②-2，C6-(2)-⑥-1，C6-(5)-①-1，C6-(5)-②-1，C6-(5)-②-2，C6-(5)-②-3，C6-(5)-②-4，C6-(5)-②-5，C6-(5)-④-1，C6-(5)-④-2，C6-(5)-⑤-3】
Please fill in the class improvement questionnaire which is carried out on all classes. Instructors will reflect on your feedback and utilize the information for improving their teaching.

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