L5003004 Genome Science II

Hiroshima University Syllabus

Japanese

Academic Year 2024Year School/Graduate School School of Applied Biological Science

Lecture Code L5003004 Subject Classification Specialized Education

Subject Name ゲノム科学II

Subject Name
（Katakana）ゲノムカガクII

Subject Name in
English Genome Science II

Instructor FUJIKAWA YUKICHI,SAMBONGI YOSHIHIRO,FUJII SOTARO

Instructor
(Katakana) フジカワ　ユキチ,サンボンギ　ヨシヒロ,フジイ　ソウタロウ

Campus Higashi-Hiroshima Semester/Term 2nd-Year,  Second Semester,  3Term

Days, Periods, and Classrooms (3T) Fri1-4：ABS C301

Lesson Style Lecture Lesson Style
(More Details) 　

Lecture

Credits 2.0 Class Hours/Week 　 Language of Instruction J : Japanese

Course Level 3 : Undergraduate High-Intermediate

Course Area（Area） 26 : Biological and Life Sciences

Course Area（Discipline） 01 : Agricultural Sciences

Eligible Students The required subject of the Molecular Agro-Life Science Program

Keywords Check keywords in the Class schedule below.

Special Subject for Teacher Education 　 Special Subject 　

Class Status
within Educational
Program
(Applicable only to targeted subjects for undergraduate students)
Criterion referenced
Evaluation
(Applicable only to targeted subjects for undergraduate students) Food Science Program
（Knowledge and Understanding）
・Ability for comprehensive and crossdisciplinary thinking and knowledge / understandings required to see a phenomena from a broad, top-down perspective and to take action for solving problems regarding the specialized area.
・Basic knowledge of such as chemistry, biology, biochemistry, microbiology, physics, and mathematics required for understanding food science.

Molecular Agro-Life Science Program
（Knowledge and Understanding）
・Knowledge and understanding regarding organic molecule, cell, individual organism, and population

Class Objectives
/Class Outline Students will learn about the basics of protein and enzyme chemistry, especially about properties and characteristics of enzyme/protein.
Lecture will be provided by two or three faculty members of the Molecular Agro-Life Science Program.

Class Schedule Lesson1: Amino acids and four levels of organization in the structure of the protein （Sambongi）
  Polypeptide, side chain, noncovalent bond, primary structure, secondary structure, tertiary structure, quaternary structure
Lesson2: Protein conformation and bond angle in polypeptide(Sambongi,Fujii),
  Ramachandran plot, α helix, β sheet, domain
Lesson3: Various proteins found in organisms(Sambongi),
  Hemoglobin, actin,  collagen, capsid of virus, amyloid, prion disease
Lesson4: How cells obtain energy from food(Sambongi),
  ATP, glycolysis, citric acid cycle, substrate-level phosphorylation
Lesson5: Mitochondria and its energy conversion(Sambongi),
  Chemiosmotic coupling, respiratory chain, ATP synthase, oxidative phosphorylation
Lesson6: Chloroplasts and photosynthesis　Light reaction and Dark reaction(Sambongi),
  Chlorophyll, Charge separation, Photosystem, Cytochrome bf, Z scheme, Ferredoxin-NADP+ reductase, Calvin cycle, Rubisco, Photorespiration, C4 photosynthesis
Lesson7:Examination (Lesson 1 to 6)　（Sambongi, Fujii)

Lesson8: Catalytic reaction of cell（Fujikawa)
  Chemical reaction, enzyme reaction, enzyme specificity
Lesson9: Enzyme catalytic mechanism 1（Fujikawa)
Transition state theory, catalytic group, binding site
Lesson10:Enzyme catalytic mechanism 2（Fujikawa)
General acid / base catalyst, covalent bond catalyst, reaction induction
Lesson11: Kinetics of enzyme（Fujikawa)
Substrate concentration, enzyme reaction rate, Michaelis constant
Lesson12:  Regulation mechanism of enzyme activity（Fujikawa)
Inhibitor
Lesson13: Regulation mechanism of enzyme activity I（Fujikawa)
temperature, pH ,Regulator, covalent chemical modification, limited hydrolysis
Lesson14:  Regulation mechanism of enzyme activity II（Fujikawa)
Lesson15: Examination (Lesson 8 to 14)　（Fujikawa)

Lesson 1 to 6: Examination
Lesson 8 to 14: Examination

Text/Reference
Books,etc. Molecular Biology of the Cell 4th, 5th, and 6th editions

PC or AV used in
Class,etc. 　

(More Details) Handouts, Projector

Learning techniques to be incorporated 　

Suggestions on
Preparation and
Review Before taking each lesson, study the meaning of keywords.
After each lesson, review the lesson.

Requirements

Grading Method Examination
(A student, absent over 5 times, is not subject to an academic assessment)

Practical Experience

Summary of Practical Experience and Class Contents based on it

Message

Other

Please fill in the class improvement questionnaire which is carried out on all classes.
Instructors will reflect on your feedback and utilize the information for improving their teaching.

Academic Year	2024Year	School/Graduate School	School of Applied Biological Science
Lecture Code	L5003004	Subject Classification	Specialized Education
Subject Name	ゲノム科学II
Subject Name （Katakana）	ゲノムカガクII
Subject Name in English	Genome Science II
Instructor	FUJIKAWA YUKICHI,SAMBONGI YOSHIHIRO,FUJII SOTARO
Instructor (Katakana)	フジカワ　ユキチ,サンボンギ　ヨシヒロ,フジイ　ソウタロウ
Campus	Higashi-Hiroshima	Semester/Term	2nd-Year, Second Semester, 3Term
Days, Periods, and Classrooms	(3T) Fri1-4：ABS C301
Lesson Style	Lecture	Lesson Style (More Details)
Lecture
Credits	2.0	Class Hours/Week		Language of Instruction	J : Japanese
Course Level	3 : Undergraduate High-Intermediate
Course Area（Area）	26 : Biological and Life Sciences
Course Area（Discipline）	01 : Agricultural Sciences
Eligible Students	The required subject of the Molecular Agro-Life Science Program
Keywords	Check keywords in the Class schedule below.
Special Subject for Teacher Education		Special Subject
Class Status within Educational Program (Applicable only to targeted subjects for undergraduate students)
Criterion referenced Evaluation (Applicable only to targeted subjects for undergraduate students)	Food Science Program （Knowledge and Understanding）・Ability for comprehensive and crossdisciplinary thinking and knowledge / understandings required to see a phenomena from a broad, top-down perspective and to take action for solving problems regarding the specialized area. ・Basic knowledge of such as chemistry, biology, biochemistry, microbiology, physics, and mathematics required for understanding food science. Molecular Agro-Life Science Program （Knowledge and Understanding）・Knowledge and understanding regarding organic molecule, cell, individual organism, and population
Class Objectives /Class Outline	Students will learn about the basics of protein and enzyme chemistry, especially about properties and characteristics of enzyme/protein. Lecture will be provided by two or three faculty members of the Molecular Agro-Life Science Program.
Class Schedule	Lesson1: Amino acids and four levels of organization in the structure of the protein （Sambongi） Polypeptide, side chain, noncovalent bond, primary structure, secondary structure, tertiary structure, quaternary structure Lesson2: Protein conformation and bond angle in polypeptide(Sambongi,Fujii), Ramachandran plot, α helix, β sheet, domain Lesson3: Various proteins found in organisms(Sambongi), Hemoglobin, actin, collagen, capsid of virus, amyloid, prion disease Lesson4: How cells obtain energy from food(Sambongi), ATP, glycolysis, citric acid cycle, substrate-level phosphorylation Lesson5: Mitochondria and its energy conversion(Sambongi), Chemiosmotic coupling, respiratory chain, ATP synthase, oxidative phosphorylation Lesson6: Chloroplasts and photosynthesis　Light reaction and Dark reaction(Sambongi), Chlorophyll, Charge separation, Photosystem, Cytochrome bf, Z scheme, Ferredoxin-NADP+ reductase, Calvin cycle, Rubisco, Photorespiration, C4 photosynthesis Lesson7:Examination (Lesson 1 to 6)　（Sambongi, Fujii) Lesson8: Catalytic reaction of cell（Fujikawa) Chemical reaction, enzyme reaction, enzyme specificity Lesson9: Enzyme catalytic mechanism 1（Fujikawa) Transition state theory, catalytic group, binding site Lesson10:Enzyme catalytic mechanism 2（Fujikawa) General acid / base catalyst, covalent bond catalyst, reaction induction Lesson11: Kinetics of enzyme（Fujikawa) Substrate concentration, enzyme reaction rate, Michaelis constant Lesson12: Regulation mechanism of enzyme activity（Fujikawa) Inhibitor Lesson13: Regulation mechanism of enzyme activity I（Fujikawa) temperature, pH ,Regulator, covalent chemical modification, limited hydrolysis Lesson14: Regulation mechanism of enzyme activity II（Fujikawa) Lesson15: Examination (Lesson 8 to 14)　（Fujikawa) Lesson 1 to 6: Examination Lesson 8 to 14: Examination
Text/Reference Books,etc.	Molecular Biology of the Cell 4th, 5th, and 6th editions
PC or AV used in Class,etc.
(More Details)	Handouts, Projector
Learning techniques to be incorporated
Suggestions on Preparation and Review	Before taking each lesson, study the meaning of keywords. After each lesson, review the lesson.
Requirements
Grading Method	Examination (A student, absent over 5 times, is not subject to an academic assessment)
Practical Experience
Summary of Practical Experience and Class Contents based on it
Message
Other
Please fill in the class improvement questionnaire which is carried out on all classes. Instructors will reflect on your feedback and utilize the information for improving their teaching.

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