Hiroshima University Syllabus

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Academic Year 2024Year School/Graduate School School of Science
Lecture Code HJ265000 Subject Classification Specialized Education
Subject Name 生体高分子化学
Subject Name
Subject Name in
Biopolymer Chemistry
タテ シンイチ,ヤスダ キョウタ
Campus Higashi-Hiroshima Semester/Term 3rd-Year,  Second Semester,  4Term
Days, Periods, and Classrooms (4T) Tues1-2,Fri1-2:SCI E104
Lesson Style Lecture Lesson Style
(More Details)
PPT is used for lecture. Handout is delivered at each class. Original text is given at the 1st class.  
Credits 2.0 Class Hours/Week   Language of Instruction J : Japanese
Course Level 3 : Undergraduate High-Intermediate
Course Area(Area) 26 : Biological and Life Sciences
Course Area(Discipline) 03 : Basic Biology
Eligible Students Bachelor students in the third grade
Keywords Protein chemistry, Biomolecular analysis, Drug discovery, Intrinsically disordered proteins, Protein-misfolding disease, Biophysics 
Special Subject for Teacher Education   Special Subject  
Class Status
within Educational
(Applicable only to targeted subjects for undergraduate students)
This lecture aims to give advanced knowledge on the interdisciplinary studies between chemistry and life science.  Students may learn how the basic chemistry can be applied to the complicated biomolecular structure analyses.  
Criterion referenced
(Applicable only to targeted subjects for undergraduate students)
(Knowledge and Understanding)
・Understanding and learning advanced expertise in several chemical and interdisciplinary areas. 
Class Objectives
/Class Outline
Students will get the basics on various experimental methods to explore structure and function relationships of biomolecules, in particular proteins. The recent topics in protein chemistry, including protein-misfolding diseases such as Alzheimer's disease and intrinsically disordered proteins, will be given.  
Class Schedule lesson1: Introduction to protein chemistry: protein chemistry in drug discovery
lesson2: Protein structure 1: amino acid sequence, secondary structures
lesson3: Protein structure 2: tertiary- and quaternary-structures and enzymatic reactions
lesson4: Protein structure 3: chemical bonds to fold protein structures
lesson5: Chemical analysis of proteins: Mass analysis of proteins
lesson6: Spectroscopy on proteins 1: UV- and Fluorescent-spectroscopies
lesson7: Spectroscopy on proteins 2: ORD, CD, and SPR
lesson8: Spectroscopy on proteins 3: Vibrational spectroscopy (IR and Raman)
lesson9: Spectroscopy on proteins 4: Magnetic resonance (NMR and ESR)
lesson10: Biopolymer in live material
lesson11: Biochemical analysis: extraction of biopolymer and their detection (Basic)
lesson12: Biochemical analysis: extraction of biopolymer and their detection (Advanced)
lesson13: Cell biological analysis: Imaging the biopolymer in live (Basic microscopy)
lesson14: Cell biological analysis: Imaging the biopolymer in live (Advanced microscopy)
lesson15: Summing up the lecture

Term end exam., Short quiz at each class, Assignment

The assignment to revise what you learned in the lecture will be given at the 14th class.  
Presentation materials are available on Moodle. No additional text bookds are required.  
PC or AV used in
(More Details) The handout at each class will be given. 
Learning techniques to be incorporated  
Suggestions on
Preparation and
At each class, you are required to answer the quiz on Bb9 to revise what you learned.  
Grading Method Term-end exam. (50%), Short quiz (15 classes, 30%), Assignment (20%) 
Practical Experience  
Summary of Practical Experience and Class Contents based on it  
Message Students do not need to memorize what you learned. Instead, they are required to get to know how to use the knowledge of basic chemistry to analyze the highly complicated biomolecules.  
Other From my experiences in the collaborative project with several pharmaceutical companies, I will sometimes mention to the topics on the drug discovery.  
Please fill in the class improvement questionnaire which is carried out on all classes.
Instructors will reflect on your feedback and utilize the information for improving their teaching. 
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