HJ150000 Chemistry of Biological Compounds

Hiroshima University Syllabus

Japanese

Academic Year 2024Year School/Graduate School School of Science

Lecture Code HJ150000 Subject Classification Specialized Education

Subject Name 生体物質化学

Subject Name
（Katakana）セイタイブッシツカガク

Subject Name in
English Chemistry of Biological Compounds

Instructor IZUMI SYUNSUKE

Instructor
(Katakana) イズミ　シュンスケ

Campus Higashi-Hiroshima Semester/Term 2nd-Year, Second Semester, 4Term

Days, Periods, and Classrooms (4T) Tues3-4,Thur7-8：ECON B157

Lesson Style Lecture Lesson Style
(More Details) 　

.

Credits 2.0 Class Hours/Week 　 Language of Instruction J : Japanese

Course Level 2 : Undergraduate Low-Intermediate

Course Area（Area） 25 : Science and Technology

Course Area（Discipline） 07 : Chemistry

Eligible Students

Keywords Carbohydrate · Stereochemistry · Lipid · Physiologically Active Substance · Biological Membrane · Amino Acid · Isoelectric Point · Protein · Structural Hierarchy · Protein Purification · Primary Sequence Determination of Protein

Special Subject for Teacher Education 　 Special Subject 　

Class Status
within Educational
Program
(Applicable only to targeted subjects for undergraduate students) It is a subject of organic chemistry class in the chemistry program.
(Learn the basics of biochemistry.)
Criterion referenced
Evaluation
(Applicable only to targeted subjects for undergraduate students) Chemistry
（Knowledge and Understanding）
・Understanding and learning advanced expertise in several chemical and interdisciplinary areas.

Class Objectives
/Class Outline .Such as physiologically active substances, biologically constructed substances, bioenergetic substances, genetic information substances
Outline the basic structure on the chemical structure and properties of biological substances and understand how they are involved in biological phenomena (biological functions) from the viewpoint of substance interaction and chemical reaction.

Class Schedule lesson1.Introduction of first lesson and experiment of demonstration
Exhibition presentation for the distribution of materials, the lesson plans / goal commentary, the relevance to chemical Ⅱ in upper secondary schools, the continuity with organic chemistry, the interest indication for evoking interest
2 nd Chemical of Carbohydrate I
Structure of carbohydrate, classification of carbohydrate, stereoisomer
Keywords: general formula · display method · D type arrangement · aldose · ketose
【Quiz test】 Small test on stereochemistry. "Knowledge", "intellectual ability / skill 1" are evaluated.
The 3rd Chemistry of Carbohydrates II
Chemical properties, monosaccharide derivatives, disaccharides
Keywords: reducing, uronic acid, sugar alcohol, sucrose
4th Chemistry of Carbohydrates III
Polysaccharides, storage polysaccharides and structural polysaccharides, complex polysaccharides
Key words: starch, glycogen, heparin, glycoprotein, dietary fiber (possibility of cutting depending on progress of lecture)
【Practicum in class】 We conduct exercises on the structure of carbohydrates. "Knowledge", "intellectual ability / skill 2" effectively.
Fifth Lipid Chemistry I
(General) structure of lipids, classification of lipids, fatty acids
Key words: triacylglycerol, saturated fatty acid, unsaturated fatty acid, essential fatty acid
Sixth Lipid Chemistry II
Simple lipids, phospholipids, glycolipids
Key words: neutral fat, glycerophospholipid, sphingophospholipid, glycolipid
The 7th Chemistry of Lipids III
Steroid, nature of lipid aggregate, biological membrane structure and function
Key words: cholesterol, bile acid, lipoprotein, membrane transport
【Quiz test】 A small test on the simple membrane permeation rate of substances. "Knowledge", "intellectual ability / skill 2" effectively.
The 8th Amino Acid and Protein Chemistry I
General structure of amino acids, classification of amino acids, properties of amino acids
Key words: α-amino acid, L-type arrangement, display method, indispensable amino acid (possibility of cutting depending on progress of lecture)
9 th Summary of carbohydrates · lipids · amino acids
We will summarize carbohydrates, lipids and amino acids in a test format.
The 10th Amino Acid · Protein Chemistry II
Electrochemical properties of amino acids, peptides
Keywords: ampholyte, isoelectric point, functional group, titration curve, peptide bond
【Quiz test】 Quiz of amino acid 3 letter 1 letter notation method. Evaluate "knowledge".
The 11th Amino Acid and Protein Chemistry III
Classification of proteins, electrical properties of proteins, higher order structures of proteins
This content is linked with biostructural chemistry (in charge of Professor Katayanagi).
In this lecture we will give lectures based on the organic chemistry of amino acids (residues) (eg Sequencing method by Edmer degradation etc).
Keywords: chemistry, isoelectric point, amino acid sequence, 1-4 order structure
The 12th Amino Acid · Protein Chemistry IV
Protein purification, physiological activity, structure and function
Key words: solubility, charge state, molecular weight, affinity, denaturation
【Quiz test】 Perform quizzes on higher order structures of proteins. "Knowledge", "intellectual ability / skill 1" effectively.
The 13th Mass Spectrometry I
Principle of mass spectrometry, apparatus and measurement, ionization method, ion separation method
Key words: EI, CI, FAB, magnetic field type, quadrupole, ion trap
[Reports] Common points and differences between quadrupole and ion trap. "Knowledge", "intellectual ability / skill 1, 2", "total ability / skill 6". It is contents to be learned next week, but evaluate the logic of thought.
The 14th Mass Spectrometry II
fragmentation
Keywords: molecular ion, simple cleavage, rearrangement reaction
We also conduct exercises. (Studying well for final exams)
lesson15

Text/Reference
Books,etc. .Textbooks: Although not specifically designated, the carbohydrate and lipid parts use charts in McMurry Organic Chemistry 8th Edition (bottom).

PC or AV used in
Class,etc. 　

(More Details) Text, handouts, images (image material)

Learning techniques to be incorporated 　

Suggestions on
Preparation and
Review .After the first lesson
Confirmation of the content of the lesson and review of the relevant field of high school chemistry.
After 2-4 lessons
Review and review the content of the lesson. Prepare for next lesson based on handouts.
At the end of the 4th session, the carbohydrate will be finished, so check the representative basic items
After 5-7 lessons
Review and review the content of the lesson. Prepare for next lesson based on handouts.
At the end of the seventh round, since lipid is terminated, check representative basic items.
After 8-11 lessons
Review and review the content of the lesson. Prepare for next lesson based on handouts.
For amino acids, a definite understanding of structure and notation is necessary. (Memorize what you should memorize securely)
After 12-14 lessons
Mass spectrometry is heterogeneous compared to the content of previous courses. Knowledge of physicochemistry is often required. Beforehand to review.
After the 15th class
Total confirmation of the contents of the lesson and a total review.

Requirements I do not ask at all whether I studied biology at high school.
(In statistics so far, there is no difference in the average points in this lecture between students who were studying physics at high school and students who were studying biology.

Grading Method Class performance is evaluated only by the final exam ("knowledge / understanding" overall evaluation).
70% of the final exam is a matter of questioning about knowledge, and 30% is "asking your thoughts" problem.
The evaluation viewpoint is as follows

Practical Experience

Summary of Practical Experience and Class Contents based on it

Message

Other

Please fill in the class improvement questionnaire which is carried out on all classes.
Instructors will reflect on your feedback and utilize the information for improving their teaching.

Academic Year	2024Year	School/Graduate School	School of Science
Lecture Code	HJ150000	Subject Classification	Specialized Education
Subject Name	生体物質化学
Subject Name （Katakana）	セイタイブッシツカガク
Subject Name in English	Chemistry of Biological Compounds
Instructor	IZUMI SYUNSUKE
Instructor (Katakana)	イズミ　シュンスケ
Campus	Higashi-Hiroshima	Semester/Term	2nd-Year, Second Semester, 4Term
Days, Periods, and Classrooms	(4T) Tues3-4,Thur7-8：ECON B157
Lesson Style	Lecture	Lesson Style (More Details)
.
Credits	2.0	Class Hours/Week		Language of Instruction	J : Japanese
Course Level	2 : Undergraduate Low-Intermediate
Course Area（Area）	25 : Science and Technology
Course Area（Discipline）	07 : Chemistry
Eligible Students
Keywords	Carbohydrate · Stereochemistry · Lipid · Physiologically Active Substance · Biological Membrane · Amino Acid · Isoelectric Point · Protein · Structural Hierarchy · Protein Purification · Primary Sequence Determination of Protein
Special Subject for Teacher Education		Special Subject
Class Status within Educational Program (Applicable only to targeted subjects for undergraduate students)	It is a subject of organic chemistry class in the chemistry program. (Learn the basics of biochemistry.)
Criterion referenced Evaluation (Applicable only to targeted subjects for undergraduate students)	Chemistry （Knowledge and Understanding）・Understanding and learning advanced expertise in several chemical and interdisciplinary areas.
Class Objectives /Class Outline	.Such as physiologically active substances, biologically constructed substances, bioenergetic substances, genetic information substances Outline the basic structure on the chemical structure and properties of biological substances and understand how they are involved in biological phenomena (biological functions) from the viewpoint of substance interaction and chemical reaction.
Class Schedule	lesson1.Introduction of first lesson and experiment of demonstration Exhibition presentation for the distribution of materials, the lesson plans / goal commentary, the relevance to chemical Ⅱ in upper secondary schools, the continuity with organic chemistry, the interest indication for evoking interest 2 nd Chemical of Carbohydrate I Structure of carbohydrate, classification of carbohydrate, stereoisomer Keywords: general formula · display method · D type arrangement · aldose · ketose 【Quiz test】 Small test on stereochemistry. "Knowledge", "intellectual ability / skill 1" are evaluated. The 3rd Chemistry of Carbohydrates II Chemical properties, monosaccharide derivatives, disaccharides Keywords: reducing, uronic acid, sugar alcohol, sucrose 4th Chemistry of Carbohydrates III Polysaccharides, storage polysaccharides and structural polysaccharides, complex polysaccharides Key words: starch, glycogen, heparin, glycoprotein, dietary fiber (possibility of cutting depending on progress of lecture) 【Practicum in class】 We conduct exercises on the structure of carbohydrates. "Knowledge", "intellectual ability / skill 2" effectively. Fifth Lipid Chemistry I (General) structure of lipids, classification of lipids, fatty acids Key words: triacylglycerol, saturated fatty acid, unsaturated fatty acid, essential fatty acid Sixth Lipid Chemistry II Simple lipids, phospholipids, glycolipids Key words: neutral fat, glycerophospholipid, sphingophospholipid, glycolipid The 7th Chemistry of Lipids III Steroid, nature of lipid aggregate, biological membrane structure and function Key words: cholesterol, bile acid, lipoprotein, membrane transport 【Quiz test】 A small test on the simple membrane permeation rate of substances. "Knowledge", "intellectual ability / skill 2" effectively. The 8th Amino Acid and Protein Chemistry I General structure of amino acids, classification of amino acids, properties of amino acids Key words: α-amino acid, L-type arrangement, display method, indispensable amino acid (possibility of cutting depending on progress of lecture) 9 th Summary of carbohydrates · lipids · amino acids We will summarize carbohydrates, lipids and amino acids in a test format. The 10th Amino Acid · Protein Chemistry II Electrochemical properties of amino acids, peptides Keywords: ampholyte, isoelectric point, functional group, titration curve, peptide bond 【Quiz test】 Quiz of amino acid 3 letter 1 letter notation method. Evaluate "knowledge". The 11th Amino Acid and Protein Chemistry III Classification of proteins, electrical properties of proteins, higher order structures of proteins This content is linked with biostructural chemistry (in charge of Professor Katayanagi). In this lecture we will give lectures based on the organic chemistry of amino acids (residues) (eg Sequencing method by Edmer degradation etc). Keywords: chemistry, isoelectric point, amino acid sequence, 1-4 order structure The 12th Amino Acid · Protein Chemistry IV Protein purification, physiological activity, structure and function Key words: solubility, charge state, molecular weight, affinity, denaturation 【Quiz test】 Perform quizzes on higher order structures of proteins. "Knowledge", "intellectual ability / skill 1" effectively. The 13th Mass Spectrometry I Principle of mass spectrometry, apparatus and measurement, ionization method, ion separation method Key words: EI, CI, FAB, magnetic field type, quadrupole, ion trap [Reports] Common points and differences between quadrupole and ion trap. "Knowledge", "intellectual ability / skill 1, 2", "total ability / skill 6". It is contents to be learned next week, but evaluate the logic of thought. The 14th Mass Spectrometry II fragmentation Keywords: molecular ion, simple cleavage, rearrangement reaction We also conduct exercises. (Studying well for final exams) lesson15
Text/Reference Books,etc.	.Textbooks: Although not specifically designated, the carbohydrate and lipid parts use charts in McMurry Organic Chemistry 8th Edition (bottom).
PC or AV used in Class,etc.
(More Details)	Text, handouts, images (image material)
Learning techniques to be incorporated
Suggestions on Preparation and Review	.After the first lesson Confirmation of the content of the lesson and review of the relevant field of high school chemistry. After 2-4 lessons Review and review the content of the lesson. Prepare for next lesson based on handouts. At the end of the 4th session, the carbohydrate will be finished, so check the representative basic items After 5-7 lessons Review and review the content of the lesson. Prepare for next lesson based on handouts. At the end of the seventh round, since lipid is terminated, check representative basic items. After 8-11 lessons Review and review the content of the lesson. Prepare for next lesson based on handouts. For amino acids, a definite understanding of structure and notation is necessary. (Memorize what you should memorize securely) After 12-14 lessons Mass spectrometry is heterogeneous compared to the content of previous courses. Knowledge of physicochemistry is often required. Beforehand to review. After the 15th class Total confirmation of the contents of the lesson and a total review.
Requirements	I do not ask at all whether I studied biology at high school. (In statistics so far, there is no difference in the average points in this lecture between students who were studying physics at high school and students who were studying biology.
Grading Method	Class performance is evaluated only by the final exam ("knowledge / understanding" overall evaluation). 70% of the final exam is a matter of questioning about knowledge, and 30% is "asking your thoughts" problem. The evaluation viewpoint is as follows
Practical Experience
Summary of Practical Experience and Class Contents based on it
Message
Other
Please fill in the class improvement questionnaire which is carried out on all classes. Instructors will reflect on your feedback and utilize the information for improving their teaching.

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