Hiroshima University Syllabus

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Academic Year 2024Year School/Graduate School School of Integrated Arts and Sciences Department of Integrated Arts and Sciences
Lecture Code ANL34001 Subject Classification Specialized Education
Subject Name がんの分子生物学
Subject Name
Subject Name in
Molecular Biology of Cancer
ヒラノ テツオ
Campus Higashi-Hiroshima Semester/Term 3rd-Year,  First Semester,  2Term
Days, Periods, and Classrooms (2T) Weds5-8:IAS K111
Lesson Style Lecture Lesson Style
(More Details)
Credits 2.0 Class Hours/Week   Language of Instruction J : Japanese
Course Level 3 : Undergraduate High-Intermediate
Course Area(Area) 26 : Biological and Life Sciences
Course Area(Discipline) 04 : Life Sciences
Eligible Students Students who have completed lectures including "Fundamental cell biology" and "Cell Biology"
Keywords DNA cloning, gene expression, epigenetics, RNA interference, genetic engineering, knockout mice, iPS cells, cancer, diseases 
Special Subject for Teacher Education   Special Subject  
Class Status
within Educational
(Applicable only to targeted subjects for undergraduate students)
The course aims to have students acquire the ability to understand and explain biological phenomena at the molecular level, based on the knowledge that they have acquired in the “Cell Biology” course. 
Criterion referenced
(Applicable only to targeted subjects for undergraduate students)
Integrated Arts and Sciences
(Knowledge and Understanding)
・Knowledge and understanding of the importance and characteristics of each discipline and basic theoretical framework.
(Abilities and Skills)
・The ability and skills to specify necessary theories and methods for consideration of issues.
(Comprehensive Abilities)
・The ability to conduct research proactively by combining knowledge,  understanding, and skills for the tasks, based on flexible creativity and imagination. 
Class Objectives
/Class Outline
Students will review the retention and transmission of genetic information, the mechanisms of gene expression, and the mechanisms of the expression of protein function, targeting animal cells including human cells. They will also understand the principles of DNA cloning and genetic engineering techniques as research means. Moreover, they will learn how medical and biological problems, such as cancer and immunological diseases, are understood and are addressed to be resolved. 
Class Schedule Lesson 1: Outline of the classes
Lesson 2: Chromosomes and genomic structure
Lesson 3: DNA replication and repair
Lesson 4: Control of gene expression 1 – transcription factors, epigenetics
Lesson 5: Control of gene expression 2 - post-transcriptional controls, RNA interference
Lesson 6: Oncovirus
Lesson 7: Cellular signal transduction
Lesson 8: Cell cycle
Lesson 9: Tumor suppressor gene
Lesson 10: Apoptosis
Lesson 11:  Cancer stem cells
Lesson 12: Metastasis
Lesson 13: Angiogenesis
Lesson 14: Tumor immunology
Students are required to take examinations and submit reports, as needed. 
“Essential Cell Biology” B. Alberts, et al., Nankodo Co., Ltd.
“Molecular Biology of the Cell” B. Alberts, et al., Kyoiku Sha Co., Ltd. 
PC or AV used in
(More Details) Textbooks, handouts, presentations using PowerPoint
Students are required to be able to visit Hirodai moodle, an online learning system in Hiroshima University.  
Learning techniques to be incorporated  
Suggestions on
Preparation and
Students are required to prepare answers for practice problems given in advance in each class and to give presentations for them and answer questions. 
Requirements Students will have difficulty understanding the contents of the classes if they have not taken the “Fundamental Cell Biology” and “Cell Biology” courses. 
Grading Method Evaluation is made on the basis of the mark given for class participation (presentations and active participation in discussions), examinations and reports. 
Practical Experience  
Summary of Practical Experience and Class Contents based on it  
Message Aiming at participatory learning, I require students to actively participate in discussions in the class. 
Please fill in the class improvement questionnaire which is carried out on all classes.
Instructors will reflect on your feedback and utilize the information for improving their teaching. 
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