ANL34001 Molecular Biology of Cancer

Hiroshima University Syllabus

Japanese

Academic Year 2024Year School/Graduate School School of Integrated Arts and Sciences Department of Integrated Arts and Sciences

Lecture Code ANL34001 Subject Classification Specialized Education

Subject Name がんの分子生物学

Subject Name
（Katakana）ガンノブンシセイブツガク

Subject Name in
English Molecular Biology of Cancer

Instructor HIRANO TETSUO

Instructor
(Katakana) ヒラノ　テツオ

Campus Higashi-Hiroshima Semester/Term 3rd-Year,  First Semester,  2Term

Days, Periods, and Classrooms (2T) Weds5-8：IAS K111

Lesson Style Lecture Lesson Style
(More Details) 　

Lecture

Credits 2.0 Class Hours/Week 　 Language of Instruction J : Japanese

Course Level 3 : Undergraduate High-Intermediate

Course Area（Area） 26 : Biological and Life Sciences

Course Area（Discipline） 04 : Life Sciences

Eligible Students Students who have completed lectures including "Fundamental cell biology" and "Cell Biology"

Keywords DNA cloning, gene expression, epigenetics, RNA interference, genetic engineering, knockout mice, iPS cells, cancer, diseases

Special Subject for Teacher Education 　 Special Subject 　

Class Status
within Educational
Program
(Applicable only to targeted subjects for undergraduate students) The course aims to have students acquire the ability to understand and explain biological phenomena at the molecular level, based on the knowledge that they have acquired in the “Cell Biology” course.
Criterion referenced
Evaluation
(Applicable only to targeted subjects for undergraduate students) Integrated Arts and Sciences
（Knowledge and Understanding）
・Knowledge and understanding of the importance and characteristics of each discipline and basic theoretical framework.
（Abilities and Skills）
・The ability and skills to specify necessary theories and methods for consideration of issues.
（Comprehensive Abilities）
・The ability to conduct research proactively by combining knowledge,  understanding, and skills for the tasks, based on flexible creativity and imagination.

Class Objectives
/Class Outline Students will review the retention and transmission of genetic information, the mechanisms of gene expression, and the mechanisms of the expression of protein function, targeting animal cells including human cells. They will also understand the principles of DNA cloning and genetic engineering techniques as research means. Moreover, they will learn how medical and biological problems, such as cancer and immunological diseases, are understood and are addressed to be resolved.

Class Schedule Lesson 1: Outline of the classes
Lesson 2: Chromosomes and genomic structure
Lesson 3: DNA replication and repair
Lesson 4: Control of gene expression 1 – transcription factors, epigenetics
Lesson 5: Control of gene expression 2 - post-transcriptional controls, RNA interference
Lesson 6: Oncovirus
Lesson 7: Cellular signal transduction
Lesson 8: Cell cycle
Lesson 9: Tumor suppressor gene
Lesson 10: Apoptosis
Lesson 11:  Cancer stem cells
Lesson 12: Metastasis
Lesson 13: Angiogenesis
Lesson 14: Tumor immunology
Students are required to take examinations and submit reports, as needed.

Text/Reference
Books,etc. “Essential Cell Biology” B. Alberts, et al., Nankodo Co., Ltd.
“Molecular Biology of the Cell” B. Alberts, et al., Kyoiku Sha Co., Ltd.

PC or AV used in
Class,etc. 　

(More Details) Textbooks, handouts, presentations using PowerPoint
Students are required to be able to visit Hirodai moodle, an online learning system in Hiroshima University.

Learning techniques to be incorporated 　

Suggestions on
Preparation and
Review Students are required to prepare answers for practice problems given in advance in each class and to give presentations for them and answer questions.

Requirements Students will have difficulty understanding the contents of the classes if they have not taken the “Fundamental Cell Biology” and “Cell Biology” courses.

Grading Method Evaluation is made on the basis of the mark given for class participation (presentations and active participation in discussions), examinations and reports.

Practical Experience

Summary of Practical Experience and Class Contents based on it

Message Aiming at participatory learning, I require students to actively participate in discussions in the class.

Other

Please fill in the class improvement questionnaire which is carried out on all classes.
Instructors will reflect on your feedback and utilize the information for improving their teaching.

Academic Year	2024Year	School/Graduate School	School of Integrated Arts and Sciences Department of Integrated Arts and Sciences
Lecture Code	ANL34001	Subject Classification	Specialized Education
Subject Name	がんの分子生物学
Subject Name （Katakana）	ガンノブンシセイブツガク
Subject Name in English	Molecular Biology of Cancer
Instructor	HIRANO TETSUO
Instructor (Katakana)	ヒラノ　テツオ
Campus	Higashi-Hiroshima	Semester/Term	3rd-Year, First Semester, 2Term
Days, Periods, and Classrooms	(2T) Weds5-8：IAS K111
Lesson Style	Lecture	Lesson Style (More Details)
Lecture
Credits	2.0	Class Hours/Week		Language of Instruction	J : Japanese
Course Level	3 : Undergraduate High-Intermediate
Course Area（Area）	26 : Biological and Life Sciences
Course Area（Discipline）	04 : Life Sciences
Eligible Students	Students who have completed lectures including "Fundamental cell biology" and "Cell Biology"
Keywords	DNA cloning, gene expression, epigenetics, RNA interference, genetic engineering, knockout mice, iPS cells, cancer, diseases
Special Subject for Teacher Education		Special Subject
Class Status within Educational Program (Applicable only to targeted subjects for undergraduate students)	The course aims to have students acquire the ability to understand and explain biological phenomena at the molecular level, based on the knowledge that they have acquired in the “Cell Biology” course.
Criterion referenced Evaluation (Applicable only to targeted subjects for undergraduate students)	Integrated Arts and Sciences （Knowledge and Understanding）・Knowledge and understanding of the importance and characteristics of each discipline and basic theoretical framework. （Abilities and Skills）・The ability and skills to specify necessary theories and methods for consideration of issues. （Comprehensive Abilities）・The ability to conduct research proactively by combining knowledge, understanding, and skills for the tasks, based on flexible creativity and imagination.
Class Objectives /Class Outline	Students will review the retention and transmission of genetic information, the mechanisms of gene expression, and the mechanisms of the expression of protein function, targeting animal cells including human cells. They will also understand the principles of DNA cloning and genetic engineering techniques as research means. Moreover, they will learn how medical and biological problems, such as cancer and immunological diseases, are understood and are addressed to be resolved.
Class Schedule	Lesson 1: Outline of the classes Lesson 2: Chromosomes and genomic structure Lesson 3: DNA replication and repair Lesson 4: Control of gene expression 1 – transcription factors, epigenetics Lesson 5: Control of gene expression 2 - post-transcriptional controls, RNA interference Lesson 6: Oncovirus Lesson 7: Cellular signal transduction Lesson 8: Cell cycle Lesson 9: Tumor suppressor gene Lesson 10: Apoptosis Lesson 11: Cancer stem cells Lesson 12: Metastasis Lesson 13: Angiogenesis Lesson 14: Tumor immunology Students are required to take examinations and submit reports, as needed.
Text/Reference Books,etc.	“Essential Cell Biology” B. Alberts, et al., Nankodo Co., Ltd. “Molecular Biology of the Cell” B. Alberts, et al., Kyoiku Sha Co., Ltd.
PC or AV used in Class,etc.
(More Details)	Textbooks, handouts, presentations using PowerPoint Students are required to be able to visit Hirodai moodle, an online learning system in Hiroshima University.
Learning techniques to be incorporated
Suggestions on Preparation and Review	Students are required to prepare answers for practice problems given in advance in each class and to give presentations for them and answer questions.
Requirements	Students will have difficulty understanding the contents of the classes if they have not taken the “Fundamental Cell Biology” and “Cell Biology” courses.
Grading Method	Evaluation is made on the basis of the mark given for class participation (presentations and active participation in discussions), examinations and reports.
Practical Experience
Summary of Practical Experience and Class Contents based on it
Message	Aiming at participatory learning, I require students to actively participate in discussions in the class.
Other
Please fill in the class improvement questionnaire which is carried out on all classes. Instructors will reflect on your feedback and utilize the information for improving their teaching.

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