Hiroshima University Syllabus

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Japanese
Academic Year 2023Year School/Graduate School Graduate School of Integrated Sciences for Life (Master's Course) Division of Integrated Sciences for Life Program of Mathematical and Life Sciences
Lecture Code WG124002 Subject Classification Specialized Education
Subject Name プロテオミクス
Subject Name
(Katakana)
プロテオミクス
Subject Name in
English
Proteomics
Instructor KATAYANAGI KATSUO,OOMAE EIJI
Instructor
(Katakana)
カタヤナギ カツオ,オオマエ エイジ
Campus Higashi-Hiroshima Semester/Term 1st-Year,  First Semester,  2Term
Days, Periods, and Classrooms (2T) Mon5-6,Weds3-4:Online
Lesson Style Lecture Lesson Style
(More Details)
 
By lerning how to obtain protein structure, structure data is able to utilize for the research.  
Credits 2.0 Class Hours/Week   Language of Instruction J : Japanese
Course Level 6 : Graduate Advanced
Course Area(Area) 25 : Science and Technology
Course Area(Discipline) 07 : Chemistry
Eligible Students
Keywords Protein Crystallography, solution structure, and Biochemical Function 
Special Subject for Teacher Education   Special Subject  
Class Status
within Educational
Program
(Applicable only to targeted subjects for undergraduate students)
 
Criterion referenced
Evaluation
(Applicable only to targeted subjects for undergraduate students)
 
Class Objectives
/Class Outline
Protein Crystallography is the center of the proteomics. This lecture introduces the principle of x-ray crystallograpy as well as how to utilize to structural biology. Moreover,
the solution structure by several spectroscopies are introduced. 
Class Schedule 1. The role of protein x-ray crystallography in proteomics
2. The protein function approached by protein crystallograpy
3. Electron diffraction and Neutron diffraction.
4. Spectroscopy for proteins: 1. Absorption and fluorescence.
5. Spectroscopy for proteins: 2. Circular dichroism (CD) and Nuclear Magnetic Resonance (NMR)
6. Solution structure by X-ray small angle scattering
7. The evaluation of x-ray crystallographic data on the paper.
8. The base of x-ray diffraction 1: Phases
9. The base of x-ray diffraction 2: Structure Factor
10. The base of x-ray diffraction 3: Reciprocal lattice
11. The base of x-ray diffraction 4: Ewald's sphere
12. The symmetry of the crystal
13. The symmetry of the diffraction pattern and the extinction rule
14. Protein crystallogtaphy by synchrotron radiation, and time resolved structure
15. Review 
Text/Reference
Books,etc.
Blundell & Johnson "Protein Crystallography" Academic Press
Max Perutz "Protein Structure" W.H.Freeman and Company
John R.Helliwell "Macromolecular Crystallography with Synchrotron Radiation" Cambridge University Press 
PC or AV used in
Class,etc.
 
(More Details) Projector 
Learning techniques to be incorporated  
Suggestions on
Preparation and
Review
Prints are provided as a tool to help comprehension. 
Requirements Attendance and reports are used for the evaluation. 
Grading Method Reports 
Practical Experience  
Summary of Practical Experience and Class Contents based on it  
Message This research field is the mixture of physics, chemistry and biology. 
Other   
Please fill in the class improvement questionnaire which is carried out on all classes.
Instructors will reflect on your feedback and utilize the information for improving their teaching. 
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