Hiroshima University Syllabus

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Japanese
Academic Year 2017Year School/Graduate School School of Applied Biological Science
Lecture Code L0018003 Subject Classification Specialized Education
Subject Name 遺伝学
Subject Name
(Katakana)
イデンガク
Subject Name in
English
Genetics
Instructor TSUDZUKI MASAOKI,UMINO TETSUYA,NISHIBORI MASAHIDE
Instructor
(Katakana)
ツヅキ マサオキ,ウミノ テツヤ,ニシボリ マサヒデ
Campus Higashi-Hiroshima Semester/Term 2nd-Year,  First Semester,  2Term
Days, Periods, and Classrooms (2T) Fri1-4:ABS C206
Lesson Style Lecture Lesson Style
【More Details】
Mainly lectures, blackboard use, occasional use of LCD projectors 
Credits 2 Class Hours/Week   Language on Instruction J : Japanese
Course Level 3 : Undergraduate High-Intermediate
Course Area(Area) 26 : Biological and Life Sciences
Course Area(Discipline) 26 : Agricultural Sciences
Eligible Students All courses, elective
Keywords Mendel, cell division, chromosome, livestock, fish  
Special Subject for Teacher Education   Special Subject  
Class Status
within Educational
Program
 
Criterion referenced
Evaluation
Integrated Ecoscience
(Knowledge and Understanding)
・To have knowledge for considering academically and comprehensively in order to learn a specialty. Also, to understand the knowledge.
・To have basic knowledge required for learning a specialty. Also, to understand the knowledge.

Biological Science of Fisheries
(Knowledge and Understanding)
・To understand basic knowledge required for learning a specialty.

Animal Science
(Knowledge and Understanding)
・Basic understanding and knowledge required for learning a specialty.
・Knowledge and understanding of living molecules or individual-level phenomena that relate to livestock production.

Food Science
(Knowledge and Understanding)
・Basic understanding and knowledge required for learning a specialty.

Applied Molecular and Cellular Biology
(Knowledge and Understanding)
・Basic understanding and knowledge required for learning a specialty.
(Abilities and Skills)
・Basic experimental ability and skills needed to learn a specialty. 
Class Objectives
/Class Outline
The objective of this class is to organize fundamental knowledge required in understanding genetics and recent molecular genetics, starting with the laws of Mendel and grasping the outline of genetics as a biological phenomenon. Fundamental matters regarding cell division, chromosomes and genes, Mendelian genetics, chromosome anomaly, choromosomal manipulation, and biochemical functions of genes will be discused.  
Class Schedule Lesson 1: Introduction
Explanation of how this lecture will be carried out
Explanation of history up to the discovery of Mendel’s law (Fusion theory, particle theory, heredity, cells, nuclei, genes, DNA)

Lesson 2
Explanation of the two kinds of somatic cell division, and within those, the somatic cell division that results in an organism (Cell division, somatic cell division, cell cycle, nuclear membrane, aster, chromonema, chromosome, spindle fiber, spindle)

Lesson 3
The focus is on chromosome behavior for meiosis in cell division, which creates reproductive cells. Concepts will be illustrated and explained. (Bivalent chromosome, homologous chromosome, crossover, recombinant)

Lesson 4
Explanation of how chromosomes are formed from the micro-level (Histone proteins, DNA, nucleosomes, solenoids, super solenoids)

Lesson 5
Explanation of the various anomalies in chromosomal formation from the macro-level (Inversions, translocations, deletions, duplicates)

Lesson 6: Mendelian genetics I
Explanation of Mendel’s law while citing examples of the law of segregation (Dominant, recessive, hybrid first generation, hybrid second generation, phenotypes, genotypes, gene symbols)

Lesson 7: Mendelian genetics II.
Explanation of Mendel’s law while citing examples from the law of independent assortment (Heterozygote, homozygote, separation ratio, Punnett square, backcross, test mating)

Lesson 8: Mendelian genetics III
Explanation of the law of independent assortment, including the genetic phenomena that seem to deviate from this law, citing examples (Traits, interaction, upper, lower, mouse, chicken)

Lesson 9: Mendelian genetics IV
Explanation of the genetic phenomena partially or fully deviating from Mendel’s law, with particular focus on the “chain”
Explanation of the production method of a chromosome map using “chain” phenomena (Incomplete dominance, sex-linked
inheritance, linkage, recombination, chromosome map)
 
Text/Reference
Books,etc.
Lecture format: Mainly writing on the blackboard, use of an LCD projector and OHP when necessary
Suitable handouts will be distributed.
Crow and Genetics Outline (Baifukan)
University Biology and Genetics (Shokabo)
Aquaculture and Chromosomal Manipulation (Kouseisha Kouseikaku)
 
PC or AV used in
Class,etc.
Handouts, LCD Projector 
Suggestions on
Preparation and
Review
After Lesson 1, confirm and review course content.
Before Lesson 2, prepare for lecture on cell cycle and somatic cell division using the reference books.
After Lesson 2, review and illustrate somatic cell division for deeper understanding.
Before Lesson 3, review meiosis using the reference books.
After Lesson 3, review and illustrate meiosis for deeper understanding.
Before Lesson 4 review chromosome structure using the reference books.
After Lesson 4, review the possible ways chromosomes can be illustrated and explained.
Before Lesson 5, review chromosome anomalies.
After Lesson 5, review various chromosome anomalies and illustrate and explain the concepts.
Before Lesson 6, review Mendel’s first law.
After Lesson 6, review Mendel’s first law to be able to explain it, citing examples.
Before Lesson 7, review Mendel’s second law.
After Lesson 7, review Mendel’s second law to be able to explain it, citing examples.
Before Lesson 8, re-confirm Mendel’s first and second laws.
After Lesson 8, review anomalous cases of Mendel’s second law to be able to explain it, citing examples.
Before Lesson 9, review the content of Lessons 3 and 7, the foundation of Lesson 9.
After Lesson 9, review with a particular focus on chromosome crossover in the meiotic prophase in the case of gene locus “chaining” and fully understand its significance.
Before Lesson 10, thoroughly understand the concept of gene dominance relationships.
After Lesson 10, confirm the calculation method of genetic distance through review.
Before and after Lesson 11, review the basic operations of cells and nuclear transfer method.
In Lesson 12, understand the series of processes up to the gamete formation process, meiosis, and fertilization as review.
For Lesson 13, review the chromosome movement from meiosis until after fertilization while reviewing the concepts from the 12 previous classes.
For Lesson 14, it is recommended that students review the mechanisms of human sex determination and understand the production method of the previous gynogenetic double haploid (diploid).
For Lesson 15, it is recommended that students review the mechanisms that ensure that siblings do not become clones, and understand chromosome movement during meiosis.
 
Requirements Those that have learned genetics up to now should carefully make a preparatory review. 
Grading Method The grades of the final exam will be the basis of evaluation (100 points). However, according to university regulations, students who are absent for more than a third of the total classes will not be able to take the final exam. 
Message There is a tendency to shy away, saying “Genetics is difficult.” However, if students study thoroughly, basic genetics will not be difficult. Do your best to dispel the existing preconception.  
Other   
Please fill in the class improvement questionnaire which is carried out on all classes.
Instructors will reflect on your feedback and utilize the information for improving their teaching. 
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